Direct and Indirect Genetic Effects on Aggression.
Direct and Indirect Genetic Effects on Aggression.
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DOI：
10.1016/j.bpsgos.2023.04.006
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发表时间：
2023-10
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影响因子：
--
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中科院分区：
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家庭成员在攻击性倾向上彼此相似。在双胞胎研究中，大约50%的攻击性差异可以用遗传影响来解释。然而，如果存在基因型与环境的相关机制，如父母和同胞基因型的环境表现，遗传影响可能部分反映了环境影响。在这项研究中，我们调查的重要性，间接多基因得分（PGS）的影响，攻击。我们基于3个全基因组关联研究对PGSs的影响进行了建模：早期攻击性，教育程度和注意力缺陷/多动障碍（ADHD）。在一个家庭内和家庭间的设计中，（37，796项测量，来自7740名个体，年龄3-86岁[平均值= 14.20岁，SE = 12.03]，来自3107个家庭，55%为女性），并采用传播/非传播PGS设计（42，649项测量来自6653名个体，年龄3-61岁[平均值= 11.81岁，SE = 8.68]，来自3024个家庭，55%为女性）。所有参与者都登记在荷兰双胞胎登记册上。我们没有发现任何证据的贡献，间接PGS的影响侵略无论是在家庭内和家庭之间的设计或传输/非传输PGS设计。结果表明，基于早期生活的攻击，教育程度和ADHD的PGSs的攻击显着的直接影响，虽然解释的方差很低（家庭内和家庭间：早期攻击性R2 = 0.3%，早期ADHD R2 = 0.6%，教育程度R2 = 0.7%;传播/非传播PGSs：早期攻击性R2 = 0.2%，早期ADHD R2 = 0.9%，教育程度R2 = 0.5%）。本研究中的PGSs对攻击性有直接（但无间接）影响，与先前的双胞胎和家庭研究结果一致。需要进一步研究涉及其他PGS的侵略和相关表型，以确定这一结论是否适用于侵略的整体遗传影响。
Family members resemble each other in their propensity for aggression. In twin studies, approximately 50% of the variance in aggression can be explained by genetic influences. However, if there are genotype-environment correlation mechanisms, such as environmental manifestations of parental and sibling genotypes, genetic influences may partly reflect environmental influences. In this study, we investigated the importance of indirect polygenic score (PGS) effects on aggression. We modeled the effect of PGSs based on 3 genome-wide association studies: early-life aggression, educational attainment, and attention-deficit/hyperactivity disorder (ADHD). The associations with aggression were tested in a within- and between-family design (37,796 measures from 7740 individuals, ages 3–86 years [mean = 14.20 years, SE = 12.03], from 3107 families, 55% female) and in a transmitted/nontransmitted PGS design (42,649 measures from 6653 individuals, ages 3–61 years [mean = 11.81 years, SE = 8.68], from 3024 families, 55% female). All participants are enrolled in the Netherlands Twin Register. We found no evidence for contributions of indirect PGS effects on aggression in either a within- and between-family design or a transmitted/nontransmitted PGS design. Results indicate significant direct effects on aggression for the PGSs based on early-life aggression, educational attainment, and ADHD, although explained variance was low (within- and between-family: early-life aggression R2 = 0.3%, early-life ADHD R2 = 0.6%, educational attainment R2 = 0.7%; transmitted/nontransmitted PGSs: early-life aggression R2 = 0.2%, early-life ADHD R2 = 0.9%, educational attainment R2 = 0.5%). PGSs included in the current study had a direct (but no indirect) effect on aggression, consistent with results of previous twin and family studies. Further research involving other PGSs for aggression and related phenotypes is needed to determine whether this conclusion generalizes to overall genetic influences on aggression.
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基因发现和多基因预测，从基因组全基因组协会的教育程度研究中，有110万个人。
影响因子：
30.8
作者：
Lee JJ;Wedow R;Okbay A;Kong E;Maghzian O;Zacher M;Nguyen-Viet TA;Bowers P;Sidorenko J;Karlsson Linnér R;Fontana MA;Kundu T;Lee C;Li H;Li R;Royer R;Timshel PN;Walters RK;Willoughby EA;Yengo L;23andMe Research Team;COGENT (Cognitive Genomics Consortium);Social Science Genetic Association Consortium;Alver M;Bao Y;Clark DW;Day FR;Furlotte NA;Joshi PK;Kemper KE;Kleinman A;Langenberg C;Mägi R;Trampush JW;Verma SS;Wu Y;Lam M;Zhao JH;Zheng Z;Boardman JD;Campbell H;Freese J;Harris KM;Hayward C;Herd P;Kumari M;Lencz T;Luan J;Malhotra AK;Metspalu A;Milani L;Ong KK;Perry JRB;Porteous DJ;Ritchie MD;Smart MC;Smith BH;Tung JY;Wareham NJ;Wilson JF;Beauchamp JP;Conley DC;Esko T;Lehrer SF;Magnusson PKE;Oskarsson S;Pers TH;Robinson MR;Thom K;Watson C;Chabris CF;Meyer MN;Laibson DI;Yang J;Johannesson M;Koellinger PD;Turley P;Visscher PM;Benjamin DJ;Cesarini D
通讯作者：
Cesarini D
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
DOI：
10.1002/ajmg.b.32784
发表时间：
2020-05-01
影响因子：
2.8
作者：
Jami, Eshim S.;Eilertsen, Espen Moen;Middeldorp, Christel M.
通讯作者：
Middeldorp, Christel M.
影响因子：
6.8
作者：
Jami ES;Hammerschlag AR;Bartels M;Middeldorp CM
通讯作者：
Middeldorp CM
影响因子：
0.9
作者：
Ligthart, Lannie;van Beijsterveldt, Catharina E. M.;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.