Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.
Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.
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DOI：
10.1038/s41398-021-01300-2
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发表时间：
2021-04-01
影响因子：
6.8
通讯作者：
Middeldorp CM
中科院分区：
文献类型：
--
作者：
Jami ES;Hammerschlag AR;Bartels M;Middeldorp CM
在观察性研究中，各种父母特征，包括精神障碍和养育行为，与后代的心理健康和相关结果有关。遗传信息设计的应用对于解开这些观察结果背后的遗传和环境因素（以及基因-环境相关性）的作用至关重要，因为父母不仅提供养育环境，而且还将50%的基因传递给后代。本文首先概述了行为遗传学、配对和分子遗传学设计，这些设计可以应用于调查亲子关系，同时建模或解释遗传效应。然后，我们对自2014年以来发表的遗传信息研究进行了系统的文献综述，这些研究调查了父母特征与后代心理健康及相关结果之间的关联。审查的研究提供了可靠的证据，抑郁症，犯罪行为，教育程度和物质使用的遗传传播。这些结果强调，不使用遗传信息设计的研究可能会误解这些亲子关联的机制。在考虑了遗传效应之后，父母的一些特征，包括父母的精神特征和养育行为，通过环境途径与后代的内化问题、外化问题、教育程度、物质使用和个性相关。总体而言，遗传信息设计研究代际传递证明是有价值的理解后代心理健康和相关结果的个体差异，以及家庭内的传播机制。
Various parental characteristics, including psychiatric disorders and parenting behaviours, are associated with offspring mental health and related outcomes in observational studies. The application of genetically informative designs is crucial to disentangle the role of genetic and environmental factors (as well as gene–environment correlation) underlying these observations, as parents provide not only the rearing environment but also transmit 50% of their genes to their offspring. This article first provides an overview of behavioural genetics, matched-pair, and molecular genetics designs that can be applied to investigate parent–offspring associations, whilst modelling or accounting for genetic effects. We then present a systematic literature review of genetically informative studies investigating associations between parental characteristics and offspring mental health and related outcomes, published since 2014. The reviewed studies provide reliable evidence of genetic transmission of depression, criminal behaviour, educational attainment, and substance use. These results highlight that studies that do not use genetically informative designs are likely to misinterpret the mechanisms underlying these parent–offspring associations. After accounting for genetic effects, several parental characteristics, including parental psychiatric traits and parenting behaviours, were associated with offspring internalising problems, externalising problems, educational attainment, substance use, and personality through environmental pathways. Overall, genetically informative designs to study intergenerational transmission prove valuable for the understanding of individual differences in offspring mental health and related outcomes, and mechanisms of transmission within families.
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影响因子：
2.6
作者：
Eaves, Lindon J.;St Pourcain, Beate;Smith, George Davey;York, Timothy P.;Evans, David M.
通讯作者：
Evans, David M.
影响因子：
3.3
作者：
Brooker, Rebecca J.;Neiderhiser, Jenae M.;Reiss, David
通讯作者：
Reiss, David
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3.7
作者：
Bridgett, David J.;Ganiban, Jody M.;Leve, Leslie D.
通讯作者：
Leve, Leslie D.
影响因子：
8.2
作者：
Ayorech, Ziada;Krapohl, Eva;von Stumm, Sophie
通讯作者：
von Stumm, Sophie
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM