Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells.
Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells.
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DOI：
10.1371/journal.pone.0090855
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
von Herrath M
中科院分区：
文献类型：
--
作者：
Baca Jones C;Filippi C;Sachithanantham S;Rodriguez-Calvo T;Ehrhardt K;von Herrath M
Elevated levels of systemic IL-10 have been associated with several chronic viral infections, including HCV, EBV, HCMV and LCMV. In the chronic LCMV infection model, both elevated IL-10 and enhanced infection of dendritic cells (DCs) are important for viral persistence. This report highlights the relationship between enhanced viral tropism for DCs and the induction of IL-10 in CD4 T cells, which we identify as the most frequent IL-10-expressing cell type in chronic LCMV infection. Here we report that infected CD8αneg DCs express elevated IL-10, induce IL-10 expression in LCMV specific CD4 T cells, and suppress LCMV-specific T cell proliferation. DCs exposed in vivo to persistent LCMV retain the capacity to stimulate CD4 T cell proliferation but induce IL-10 production by both polyclonal and LCMV-specific CD4 T cells. Our study delineates the unique effects of direct infection versus viral exposure on DCs. Collectively these data point to enhanced infection of DCs as a key trigger of the IL-10 induction cascade resulting in maintenance of elevated IL-10 expression in CD4 T cells and inhibition of LCMV-specific CD4 and CD8 T cell proliferation.
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影响因子：
32.4
作者：
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通讯作者：
Flavell, Richard A.
影响因子：
5.4
作者：
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影响因子：
7.3
作者：
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通讯作者：
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影响因子：
15.9
作者：
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通讯作者：
Wherry, E. John
DOI：
10.1073/pnas.1201586109
发表时间：
2012-03-20
影响因子：
11.1
作者：
Eisen, Herman N.;Hou, Xun Helen;Cohen, Richard J.
通讯作者：
Cohen, Richard J.