Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke.
Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke.
复制标题
成纤维细胞生长因子在缺血性中风治疗中的作用及其治疗潜力
DOI：
10.3389/fphar.2021.671131
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发表时间：
2021
影响因子：
5.6
通讯作者：
Lin L
中科院分区：
文献类型：
--
作者：
Dordoe C;Chen K;Huang W;Chen J;Hu J;Wang X;Lin L
中风是全世界主要的死亡原因，其治疗仍然是一个挑战。中风涉及复杂的病理过程，导致大脑的氧气和能量供应减少，从而触发随后的级联事件，如氧化应激、炎症反应和细胞凋亡，导致脑损伤。中风是一种毁灭性的疾病，治疗方法很少，但物理康复可以帮助改善中风的康复。尽管治疗中风患者的方法很少，但在哺乳动物中发现成纤维细胞生长因子(FGFs)，导致在动物模型中发现FGFs可以有效地治疗中风。在这篇综述中，FGFs作为动态平衡因子和控制新陈代谢中的细胞和激素发挥着重要的作用。它们可作为治疗中风的有效药物。本文综述了FGFs在治疗缺血性卒中中的多靶点药理作用，包括直接促进神经元存活、促进血管生成、保护血脑屏障(BBB)破坏、调节小胶质细胞调节的能力、其作用机制和作用，以及FGFs在临床治疗卒中中的治疗潜力和局限性。
Stroke is the leading cause of death worldwide, and its treatment remains a challenge. Complex pathological processes are involved in stroke, which causes a reduction in the supply of oxygen and energy to the brain that triggers subsequent cascade events, such as oxidative stress, inflammatory responses and apoptosis, resulting in brain injury. Stroke is a devastating disease for which there are few treatments, but physical rehabilitation can help improve stroke recovery. Although there are very few treatments for stroke patients, the discovery of fibroblast growth factors (FGFs) in mammals has led to the finding that FGFs can effectively treat stroke in animal models. As presented in this review, FGFs play essential roles by functioning as homeostatic factors and controlling cells and hormones involved in metabolism. They could be used as effective therapeutic agents for stroke. In this review, we will discuss the pharmacological actions of FGFs on multiple targets, including their ability to directly promote neuron survival, enhance angiogenesis, protect against blood-brain barrier (BBB) disruption, and regulate microglial modulation, in the treatment of ischemic stroke and their theoretical mechanisms and actions, as well as the therapeutic potential and limitations of FGFs for the clinical treatment of stroke.
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