Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload.
Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload.
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DOI：
10.1016/j.pbiomolbio.2016.11.004
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发表时间：
2016-12
影响因子：
3.8
通讯作者：
Omens, Jeffrey H.
中科院分区：
文献类型：
--
作者：
Carruth, Eric D.;McCulloch, Andrew D.;Omens, Jeffrey H.
关键词：
尽管对整个心脏的激活、收缩和变形的真正完整的理解远远超出了我们目前的能力范围，但为了更好地治疗心脏病患者，我们已经投入了大量的努力来发现和理解心肌结构决定心脏功能的机制。多项实验研究表明，跨壁纤维应变在舒张期和收缩期都相对均匀，这与传统力学理论的预测相反。同样，数学模型在很大程度上预测了整个壁上的均匀纤维应力。在充盈和射血过程中纤维应力和应变的这种均匀模式的发展是由于几种心肌结构的不均匀跨壁分布。这篇综述总结了这些透壁梯度、它们对纤维力学的贡献，以及它们在压力过载肥大过程中重塑的潜在功能效应。
Although a truly complete understanding of whole heart activation, contraction, and deformation is well beyond our current reach, a significant amount of effort has been devoted to discovering and understanding the mechanisms by which myocardial structure determines cardiac function to better treat patients with cardiac disease. Several experimental studies have shown that transmural fiber strain is relatively uniform in both diastole and systole, in contrast to predictions from traditional mechanical theory. Similarly, mathematical models have largely predicted uniform fiber stress across the wall. The development of this uniform pattern of fiber stress and strain during filling and ejection is due to heterogeneous transmural distributions of several myocardial structures. This review summarizes these transmural gradients, their contributions to fiber mechanics, and the potential functional effects of their remodeling during pressure overload hypertrophy.
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