Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients.
Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients.
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SARS患者的临床表现，实验室发现和治疗结果。
DOI：
10.3201/eid1005.030640
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发表时间：
2004-05
影响因子：
11.8
通讯作者：
Yang PC
中科院分区：
文献类型：
--
作者：
Wang JT;Sheng WH;Fang CT;Chen YC;Wang JL;Yu CJ;Chang SC;Yang PC
关于严重急性呼吸系统综合征（SARS）的临床和实验室数据，特别是关于异常实验室结果的时间进展的数据有限。我们对2003年3月8日至6月15日在台湾大学附属医院住院的SARS合并肺炎患者的临床、放射学及血液学表现进行前瞻性研究。发烧是最常见的初始症状，其次是咳嗽、肌痛、呼吸困难和腹泻。24名患者有各种潜在疾病。大多数患者c反应蛋白（CRP）水平升高，淋巴细胞减少。其他常见的异常实验室结果包括白细胞减少、血小板减少、转氨酶、乳酸脱氢酶和肌酸激酶水平升高。这些临床和实验室结果在大多数患者患病第二周时加重。总病死率为19.7%。通过多因素分析，基础疾病和初始CRP水平可预测死亡。
Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.
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影响因子：
8.8
作者：
Hund, EF;Fogel, W;Hacke, W
通讯作者：
Hacke, W
DOI：
10.1016/s0140-6736(03)13376-4
发表时间：
2003-05-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
World Health Organization Multicentre Collaborative Network for Severe Acute Respiratory Syndrome Diagnosis
通讯作者：
World Health Organization Multicentre Collaborative Network for Severe Acute Respiratory Syndrome Diagnosis
影响因子：
2.7
作者：
Berger, JR;Sabet, A
通讯作者：
Sabet, A
DOI：
10.1001/jama.289.21.joc30885
发表时间：
2003-06-04
影响因子：
120.7
作者：
Booth, CM;Matukas, LM;Detsky, AS
通讯作者：
Detsky, AS
DOI：
10.1016/s0140-6736(03)13265-5
发表时间：
2003-05-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
So LK;Lau AC;Yam LY;Cheung TM;Poon E;Yung RW;Yuen KY
通讯作者：
Yuen KY