A multicentre collaboration to investigate the cause of severe acute respiratory syndrome.
A multicentre collaboration to investigate the cause of severe acute respiratory syndrome.
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DOI：
10.1016/s0140-6736(03)13376-4
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发表时间：
2003-05-17
期刊：
影响因子：
--
通讯作者：
World Health Organization Multicentre Collaborative Network for Severe Acute Respiratory Syndrome Diagnosis
中科院分区：
文献类型：
--
作者：
World Health Organization Multicentre Collaborative Network for Severe Acute Respiratory Syndrome Diagnosis
严重急性呼吸系统综合症是一种新的人类疾病，于2003年2月下旬在越南河内首次被发现。这种疾病的严重性，加上它沿着国际航空路线的迅速传播，促使世卫组织建立了一个由来自世界各地11个实验室的科学家组成的网络，试图确定病原体并开发一种诊断测试。该网络将具有不同方法和能力的实验室联合起来，以迅速满足确定病毒为疾病病因的所有假设。结果通过一个安全的网站进行真实的实时共享，该网站上还发布了显微镜照片、测试方案和PCR引物序列。在每日电话会议中讨论调查结果。通过实验室之间分享样品和测试材料，进一步促进了进展。该网络已经确定了一种新的冠状病毒，在几个国家的SARS患者样本中不断检测到，并最终将其命名为SARS的病原体;该菌株不同于冠状病毒属的任何其他已知成员。现在有三种诊断测试，但都有局限性。
Severe Acute respiratory syndrome is a new disease in human beings, first recognised in late February, 2003, in Hanoi, Vietnam. The severity of the disease, combined with its rapid spread along international air-travel routes, prompted WHO to set up a network of scientists from 11 laboratories around the world to try to identify the causal agent and develop a diagnostic test. The network unites laboratories with different methods and capacities to rapidly fulfil all postulates for establishing a virus as the cause of a disease. Results are shared in real time via a secure website, on which microscopy pictures, protocols for testing, and PCR primer sequences are also posted. Findings are discussed in daily teleconferences. Progress is further facilitated through sharing between laboratories of samples and test materials. The network has identified a new coronavirus, consistently detected in samples of SARS patients from several countries, and conclusively named it as the causative agent of SARS; the strain is unlike any other known member of the genus Coronavirus. Three diagnostic tests are now available, but all have limitations.
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影响因子：
82.9
作者：
van den Hoogen BG;de Jong JC;Groen J;Kuiken T;de Groot R;Fouchier RA;Osterhaus AD
通讯作者：
Osterhaus AD
DOI：
10.1016/s0140-6736(03)13077-2
发表时间：
2003-04-19
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者：
SARS study group
影响因子：
168.9
作者：
Claas, ECJ;Osterhaus, ADME;Webster, RG
通讯作者：
Webster, RG
影响因子：
56.9
作者：
Chua, KB;Bellini, WJ;Mahy, BWJ
通讯作者：
Mahy, BWJ
影响因子：
158.5
作者：
Goh, KJ;Tan, CT;Lam, SK
通讯作者：
Lam, SK