Predictive and prognostic value of intravoxel incoherent motion (IVIM) MR imaging in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy.
Predictive and prognostic value of intravoxel incoherent motion (IVIM) MR imaging in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy.
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DOI：
10.1038/s41598-017-11988-2
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发表时间：
2017-09-14
影响因子：
4.6
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Zhu L;Wang H;Zhu L;Meng J;Xu Y;Liu B;Chen W;He J;Zhou Z;Yang X
通过使用体素内不相干运动（IVIM）模型，可以同时获得扩散相关系数（D）和灌注相关参数（f）。在这里，我们探讨了 IVIM MR 成像在预测接受同步放化疗 (CCRT) 治疗的晚期宫颈癌患者长期预后中的应用。在这项研究中，对 30 名晚期宫颈癌女性在三个时间点（CCRT 开始前 2 周内以及开始后 2 周和 4 周内）进行了盆腔 MR 检查，包括 IVIM 序列。评估了肿瘤大小和 IVIM 衍生参数在预测长期预后中的表现。中位随访24个月（范围10∼34个月）后，25/30（83.33%）患者存活，21/30（70.00%）患者仍无疾病。最大直径收缩率（时间点 1 vs. 3） ≥ 58.31% 对于预测良好的长期预后很有用。时间点 2 的 IVIM 衍生表观扩散系数 (ADCIVIM) 值以及时间点 3 的 ADCIVIM 和 f 值在预测良好预后方面也表现良好，AUC 分别为 0.767、0.857 和 0.820。 IVIM MR 成像在预测接受 CCRT 治疗的晚期宫颈癌患者的长期预后方面具有巨大潜力。
By using the intravoxel incoherent motion (IVIM) model, the diffusion-related coefficient (D) and the perfusion-related parameter (f) can be obtained simultaneously. Here, we explored the application of IVIM MR imaging in predicting long-term prognosis in patients with advanced cervical cancers treated with concurrent chemo-radiotherapy (CCRT). In this study, pelvic MR examinations including an IVIM sequence were performed on 30 women with advanced cervical cancers at three time points (within 2 weeks before, as well as 2 and 4 weeks after, the initiation of CCRT). The performance of tumour size and IVIM-derived parameters in predicting long-term prognosis was evaluated. After a median follow-up of 24 months (range, 10∼34 months), 25/30 (83.33%) patients were alive, and 21/30 (70.00%) remained free of disease. A shrinkage rate of maximum diameter (time point 1 vs. 3) ≥ 58.31% was useful in predicting a good long-term prognosis. The IVIM-derived apparent diffusion coefficient (ADCIVIM) value at time point 2 and the ADCIVIM and f values at time point 3 also performed well in predicting a good prognosis, with AUC of 0.767, 0.857 and 0.820, respectively. IVIM MR imaging has great potential in predicting long-term prognosis in patients with advanced cervical cancers treated with CCRT.
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