The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment.
The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment.
复制标题
乙型肝炎病毒感染的代谢反应为发病机制和治疗目标提供了新的线索
DOI：
10.1038/srep08421
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发表时间：
2015-02-12
影响因子：
4.6
通讯作者：
Tang H
中科院分区：
文献类型：
--
作者：
Li H;Zhu W;Zhang L;Lei H;Wu X;Guo L;Chen X;Wang Y;Tang H
Chronic infection caused by the hepatitis B virus (HBV), is strongly associated with hepatitis, fatty liver and hepatocellular carcinoma. To investigate the underlying mechanisms, we characterize the metabolic features of host cells infected with the virus using systems biological approach. The results show that HBV replication induces systematic metabolic alterations in host cells. HBV infection up-regulates the biosynthesis of hexosamine and phosphatidylcholine by activating glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1) and choline kinase alpha (CHKA) respectively, which were reported for the first time for HBV infection. Importantly suppressing hexosamine biosynthesis and phosphatidylcholine biosynthesis can inhibit HBV replication and expression. In addition, HBV induces oxidative stress and stimulates central carbon metabolism and nucleotide synthesis. Our results also indicate that HBV associated hepatocellular carcinoma could be attributed to GFAT1 activated hexosamine biosynthesis and CHKA activated phosphatidylcholine biosynthesis. This study provides further insights into the pathogenesis of HBV-induced diseases and sheds new light on drug target for treating HBV infection.
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影响因子：
8
作者：
Hernando, E.;Sarmentero-Estrada, J.;Koppie, T.;Belda-Iniesta, C.;de Molina, V. Ramirez;Cejas, P.;Ozu, C.;Le, C.;Sanchez, J. J.;Gonzalez-Baron, M.;Koutcher, J.;Cordon-Cardo, C.;Bochner, B. H.;Lacal, J. C.;de Molina, A. Ramirez
通讯作者：
de Molina, A. Ramirez
影响因子：
4.1
作者：
Kim, KyeongJin;Kim, Kook Hwan;Cheong, JaeHun
通讯作者：
Cheong, JaeHun
DOI：
10.1038/nrc3162
发表时间：
2011-11-17
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.79.6.1698
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ESKO, JD;NISHIJIMA, M;RAETZ, CRH
通讯作者：
RAETZ, CRH
影响因子：
11.2
作者：
Glunde, Kristine;Shah, Tariq;Bhujwalla, Zaver M.
通讯作者：
Bhujwalla, Zaver M.