A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy.
A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy.
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放射治疗后小鼠脑肿瘤的纵向磁共振弹性成像研究
DOI：
10.1088/0031-9155/61/16/6121
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发表时间：
2016-08-21
影响因子：
3.5
通讯作者：
Garbow JR
中科院分区：
文献类型：
--
作者：
Feng Y;Clayton EH;Okamoto RJ;Engelbach J;Bayly PV;Garbow JR
治疗监测和治疗计划都需要一种准确且无创的方法来评估放疗后的治疗反应。单独测量实体瘤体积不足以可靠地早期检测治疗反应，因为生理和/或生物力学特性的变化可能先于治疗后肿瘤体积的变化。本研究采用磁共振弹性成像技术评价小鼠脑肿瘤模型放疗后的治疗效果。计算剪切模量，并比较划定的肿瘤感兴趣区域（ROI）与对侧镜像对应区域之间的剪切模量。我们还比较了照射和未照射肿瘤的剪切模量以及纵向镜像roi，采样了肿瘤植入后9-19 d的四个时间点。结果表明，肿瘤ROI的剪切模量低于镜像ROI，与辐射无关。无论治疗组还是未治疗组，肿瘤ROI的剪切模量都随着时间的推移而下降。相比之下，治疗组镜像ROI的剪切模量相对恒定，而未治疗组则有增加的趋势。这些结果为放疗后的肿瘤特性提供了新的见解，并证明了利用肿瘤的机械特性作为生物标志物的潜力。在未来的研究中，将采用更紧密间隔的时间点来详细分析辐射效应。
An accurate and noninvasive method for assessing treatment response following radiotherapy is needed for both treatment monitoring and planning. Measurement of solid tumor volume alone is not sufficient for reliable early detection of therapeutic response, since changes in physiological and/or biomechanical properties can precede tumor volume change following therapy. In this study, we use magnetic resonance elastography to evaluate the treatment effect after radiotherapy in a murine brain tumor model. Shear modulus was calculated and compared between the delineated tumor region of interest (ROI) and its contralateral, mirrored counterpart. We also compared the shear modulus from both the irradiated and non-irradiated tumor and mirror ROIs longitudinally, sampling four time points spanning 9–19 d post tumor implant. Results showed that the tumor ROI had a lower shear modulus than that of the mirror ROI, independent of radiation. The shear modulus of the tumor ROI decreased over time for both the treated and untreated groups. By contrast, the shear modulus of the mirror ROI appeared to be relatively constant for the treated group, while an increasing trend was observed for the untreated group. The results provide insights into the tumor properties after radiation treatment and demonstrate the potential of using the mechanical properties of the tumor as a biomarker. In future studies, more closely spaced time points will be employed for detailed analysis of the radiation effect.
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影响因子：
15.9
作者：
Dunet, Vincent;Pomoni, Anastasia;Prior, John O.
通讯作者：
Prior, John O.
DOI：
10.6004/jnccn.2014.0156
发表时间：
2014-11-01
影响因子：
13.4
作者：
Leung, Denise;Han, Xiaosi;Nabors, L. Burt
通讯作者：
Nabors, L. Burt
影响因子：
15.9
作者：
Farjam, Reza;Tsien, Christina I.;Cao, Yue
通讯作者：
Cao, Yue
影响因子：
19.7
作者：
Law, Meng;Young, Robert J.;Johnson, Glyn
通讯作者：
Johnson, Glyn
影响因子：
3.1
作者：
Bolcaen, Julie;Descamps, Benedicte;Goethals, Ingeborg
通讯作者：
Goethals, Ingeborg