Identifying genomic and metabolic features that can underlie early successional and opportunistic lifestyles of human gut symbionts.
Identifying genomic and metabolic features that can underlie early successional and opportunistic lifestyles of human gut symbionts.
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DOI：
10.1101/gr.138198.112
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发表时间：
2012-10
期刊：
影响因子：
7
通讯作者：
Knight R
中科院分区：
文献类型：
--
作者：
Lozupone C;Faust K;Raes J;Faith JJ;Frank DN;Zaneveld J;Gordon JI;Knight R
我们缺乏对遗传和代谢属性的深刻理解，这些属性专门用于微生物财团在我们身体栖息地的最初和随后的殖民化浪潮。在这里，我们表明，在梭菌簇XIVa中，一组丰富的细菌在成人肠道也被称为梭菌coccoides或直肠真杆菌组，包含的物种，已演变的分布模式与早期演替或稳定的肠道社区一致。专门针对婴儿肠道的物种更有可能与全身性感染相关，并且在炎症性肠病（IBD）患者中可以达到高丰度，这表明适应先锋/机会主义生活方式的微生物群子集可能在早期发育和疾病中表现良好。我们确定的基因可能选择在适应先锋/机会主义的生活方式为那些早期继承协会，而不是系统发育关系解释基因组丰度。这些基因揭示了机会性肠道细菌耐受渗透压和氧化应激的潜在机制及其代谢的潜在重要方面。这些基因不仅可能是与适应早期继承和干扰相关的特性的生物标志物，而且还可以引导开发旨在促进生理或病理干扰后重建稳定肠道群落的疗法。
We lack a deep understanding of genetic and metabolic attributes specializing in microbial consortia for initial and subsequent waves of colonization of our body habitats. Here we show that phylogenetically interspersed bacteria in Clostridium cluster XIVa, an abundant group of bacteria in the adult human gut also known as the Clostridium coccoides or Eubacterium rectale group, contains species that have evolved distribution patterns consistent with either early successional or stable gut communities. The species that specialize to the infant gut are more likely to associate with systemic infections and can reach high abundances in individuals with Inflammatory Bowel Disease (IBD), indicating that a subset of the microbiota that have adapted to pioneer/opportunistic lifestyles may do well in both early development and with disease. We identified genes likely selected during adaptation to pioneer/opportunistic lifestyles as those for which early succession association and not phylogenetic relationships explain genomic abundance. These genes reveal potential mechanisms by which opportunistic gut bacteria tolerate osmotic and oxidative stress and potentially important aspects of their metabolism. These genes may not only be biomarkers of properties associated with adaptation to early succession and disturbance, but also leads for developing therapies aimed at promoting reestablishment of stable gut communities following physiologic or pathologic disturbances.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
2.8
作者：
Diez-Gonzalez, F;Bond, DR;Russell, JB
通讯作者：
Russell, JB
影响因子：
4.8
作者：
Jones, CG;Lawton, JH;Shachak, M
通讯作者：
Shachak, M
影响因子：
1.2
作者：
Chan, Henry;Babayan, Vartan;Saier, Milton H., Jr.
通讯作者：
Saier, Milton H., Jr.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y