Access to clinical trials among oncology patients: results of a cross sectional survey.
Access to clinical trials among oncology patients: results of a cross sectional survey.
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DOI：
10.1186/s12885-017-3644-3
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发表时间：
2017-09-18
期刊：
影响因子：
3.8
通讯作者：
Olver I
中科院分区：
文献类型：
--
作者：
Carey M;Boyes AW;Smits R;Bryant J;Waller A;Olver I
临床试验对于癌症治疗和护理的进步是必要的，但是参与此类试验的低比例限制了研究结果的普遍性。本研究的目的是调查澳大利亚被邀请并同意参加临床试验的内科肿瘤门诊患者的比例以及与此相关的因素。从三个澳大利亚癌症治疗中心招募成人内科肿瘤患者样本。患者完成了两次纸笔调查;一次是在同意时，另一次是在大约1个月后。进行多变量logistic回归，以探讨与邀请和参与试验相关的因素。383名参与者中有38%（n = 146）报告说他们被邀请参加临床试验。在被邀请的人中，93%的人表示同意参加试验，大多数人表示他们不后悔自己的决定（89%）。治疗中心和诊断后的时间与被邀请参加临床试验显著相关。没有一个因素与临床试验同意率相关。参加临床试验的主要障碍是没有被邀请参加，患者参加的中心是他们是否被邀请的一个可改变的决定因素。增加治疗中心的可用资源，以确保所有患者都能参加他们有资格参加的试验，这可能有助于提高试验参与率。本文的在线版本（10.1186/s12885-017-3644-3）包含补充材料，可供授权用户使用。
Clinical trials are necessary for the advancement of cancer treatment and care, however low rates of participation in such trials limit the generalisability of findings. The objective of this study was to examine the proportion of medical oncology outpatients in Australia who are invited and consent to participate in clinical trials and the factors associated with this. A sample of adult medical oncology patients was recruited from three Australian cancer treatment centres. Consenting patients completed two paper-and-pencil surveys; one at the time of consent and another approximately 1 month later. A multivariate logistic regression was conducted to explore factors associated with invitation and participation in a trial. Thirty-eight percent (n = 146) of the 383 participants reported they had been invited to take part in a clinical trial. Of those invited, 93% reported consenting to participate in the trial, with the majority indicating that they did not regret their decision (89%). Treatment centre and time since diagnosis were significantly associated with being invited to take part in a clinical trial. None of the factors examined were associated with clinical trial consent rates. The main barrier to clinical trial participation is not being invited to do so, with the centre the patient attends being a modifiable determinant of whether or not they are invited. Increasing the resources available to treatment centres to ensure all patients are offered participation in trials they are eligible for may help to improve rates of trial participation. The online version of this article (10.1186/s12885-017-3644-3) contains supplementary material, which is available to authorized users.
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