Heart regeneration in adult Xenopus tropicalis after apical resection.
Heart regeneration in adult Xenopus tropicalis after apical resection.
复制标题
成年热带爪蟾心尖切除后的心脏再生
DOI：
10.1186/s13578-017-0199-6
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发表时间：
2017
影响因子：
7.5
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Liao S;Dong W;Lv L;Guo H;Yang J;Zhao H;Huang R;Yuan Z;Chen Y;Feng S;Zheng X;Huang J;Huang W;Qi X;Cai D
背景：成年哺乳动物的肌再生非常有限，但具有巨大的治疗潜力。然而，我们还远未完全理解心脏组织再生的细胞和分子机制。两栖动物的再生能力使它们成为阐明受损的成熟器官如何在成年生物体中自然重建的有力动物模型。像其他两栖动物，如蝾螈和蝾螈，成年Xenopus显示高再生能力，如视网膜。迄今为止，成年蛙心脏损伤后是否有再生能力还没有很好的描述。结果：我们观察了热带爪蟾（Xenopus tropicalis）心脏心尖切除后心脏组织的再生情况。我们第一次发现，成年人。Tropicalisheart可以在损伤后约30天通过根尖切除以几乎无疤痕的方式完美再生。我们观察到，损伤的心脏在切除后立即通过凝固被封闭，随后是短暂的纤维组织产生。最后，截肢区域由心肌细胞再生。在再生过程中，损伤后邻近心肌边缘区的心肌细胞呈高度增殖状态，为新生心脏组织的形成做出了贡献。结论：建立了成人心脏再生模型。Tropicalis提供了一个强大的工具，重演一个完美的再生现象，并阐明了潜在的分子机制的心脏再生在成年人的心脏，从这个模型的发现可能适用于哺乳动物。
Background:Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue can regenerate. The full functional ability of amphibians to regenerate makes them powerful animal models for elucidating how damaged mature organs are naturally reconstituted in an adult organism. Like other amphibians, such as newts and axolotls, adultXenopusdisplays high regenerative capacity such as retina. So far, whether the adult frog heart processes regenerative capacity after injury has not been well delineated.Results:We examined the regeneration of adult cardiac tissues ofXenopus tropicalisafter resection of heart apex. We showed, for the first time, that the adultX. tropicalisheart can regenerate perfectly in a nearly scar-free manner approximately 30 days after injury via apical resection. We observed that the injured heart was sealed through coagulation immediately after resection, which was followed by transient fibrous tissue production. Finally, the amputated area was regenerated by cardiomyocytes. During the regeneration process, the cardiomyocytes in the border area of the myocardium adjacent to the wound exhibited high proliferation after injury, thus contribute the newly formed heart tissue.Conclusions:Establishing a cardiac regeneration model in adultX. tropicalisprovides a powerful tool for recapitulating a perfect regeneration phenomenon and elucidating the underlying molecular mechanisms of cardiac regeneration in an adult heart, and findings from this model may be applicable in mammals.
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影响因子：
11.4
作者：
Harland, Richard M.;Grainger, Robert M.
通讯作者：
Grainger, Robert M.
影响因子：
56.9
作者：
Poss, KD;Wilson, LG;Keating, MT
通讯作者：
Keating, MT
DOI：
10.1073/pnas.1408233111
发表时间：
2014-06-17
影响因子：
11.1
作者：
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通讯作者：
Ardehali, Reza
影响因子：
2.7
作者：
Yoshii, Chika;Ueda, Yoko;Araki, Masasuke
通讯作者：
Araki, Masasuke
影响因子：
2.7
作者：
Witman, Nevin;Murtuza, Bari;Morrison, Jamie Ian
通讯作者：
Morrison, Jamie Ian