Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer.
Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer.
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DOI：
10.1002/mnfr.201500902
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发表时间：
2017-01
影响因子：
5.2
通讯作者：
Bultman, Scott J.
中科院分区：
文献类型：
--
作者：
Bultman, Scott J.
关键词：
尽管结肠镜筛查取得了成功，但结直肠癌（CRC）仍然是最常见和最致命的癌症之一，在一些筛查不常规且人口最近从传统饮食转向西方饮食的国家，CRC发病率正在上升。饮食和能量平衡通过多种机制影响CRC。它们调节肠道微生物群的组成和功能，肠道微生物群具有巨大的代谢能力，并且可以产生肿瘤抑制剂或肿瘤抑制代谢物，部分取决于胃肠道中存在哪些饮食因子和消化组分。肠道微生物群对固有层中的免疫细胞也有深远的影响，这会影响炎症和随后的CRC。营养物质的可利用性是饮食和能量平衡的结果，决定了某些能量代谢物的丰度，这些能量代谢物是表观遗传酶的重要辅助因子，因此影响基因表达的表观遗传调节。异常的表观遗传标记在CRC期间积累，并且选择用于通过引起转录组谱从起源细胞偏离来驱动肿瘤发生的表观突变。在某些情况下，上述机制相互交织，如通过膳食纤维被结肠细菌代谢成丁酸盐所例示的，丁酸盐既是短链脂肪酸（SCFA）又是组蛋白脱乙酰酶（HDAC）抑制剂，其表观遗传上上调CRC细胞中的肿瘤抑制基因和免疫细胞中的抗炎基因。
Despite the success of colonoscopy screening, colorectal cancer (CRC) remains one of the most common and deadly cancers, and CRC incidence is rising in some countries where screening is not routine and populations have recently switched from traditional diets to western diets. Diet and energy balance influence CRC by multiple mechanisms. They modulate the composition and function of gut microbiota, which have a prodigious metabolic capacity and can produce oncometabolites or tumor-suppressive metabolites depending, in part, on which dietary factors and digestive components are present in the GI tract. Gut microbiota also have a profound effect on immune cells in the lamina propria, which influences inflammation and subsequently CRC. Nutrient availability, which is an outcome of diet and energy balance, determines the abundance of certain energy metabolites that are essential co-factors for epigenetic enzymes and therefore impinges upon epigenetic regulation of gene expression. Aberrant epigenetic marks accumulate during CRC, and epimutations that are selected for drive tumorigenesis by causing transcriptome profiles to diverge from the cell of origin. In some instances, the above mechanisms are intertwined as exemplified by dietary fiber being metabolized by colonic bacteria into butyrate, which is both a short-chain fatty acid (SCFA) and a histone deacetylase (HDAC) inhibitor that epigenetically upregulates tumor-suppressor genes in CRC cells and anti-inflammatory genes in immune cells.
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影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
影响因子：
16.9
作者：
Bailey CE;Hu CY;You YN;Bednarski BK;Rodriguez-Bigas MA;Skibber JM;Cantor SB;Chang GJ
通讯作者：
Chang GJ
gnotobiotic小鼠模型表明，饮食纤维以微生物群和丁酸酯依赖性方式预防结肠直肠肿瘤发生。
影响因子：
28.2
作者：
Donohoe DR;Holley D;Collins LB;Montgomery SA;Whitmore AC;Hillhouse A;Curry KP;Renner SW;Greenwalt A;Ryan EP;Godfrey V;Heise MT;Threadgill DS;Han A;Swenberg JA;Threadgill DW;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
29
作者：
Donohoe DR;Garge N;Zhang X;Sun W;O'Connell TM;Bunger MK;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
3.9
作者：
Bordonaro M;Lazarova D
通讯作者：
Lazarova D