T cell homing to epithelial barriers in allergic disease.
T cell homing to epithelial barriers in allergic disease.
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作者：
过敏性炎症发生在具有暴露于环境的大上皮表面积的组织中，例如肺、皮肤和肠道。在稳定状态下，抗原经历的记忆T细胞巡逻这些外周组织，以促进对入侵病原体的快速免疫反应。在至少两个易过敏器官（皮肤和肠道）中，记忆T细胞在最初的抗原引发过程中被编程为表达运输受体，使它们能够优先回到这些器官。在这篇综述中，我们提出，组织特异性记忆和炎症特异性T细胞运输促进这些器官过敏性疾病的发展。因此，我们回顾了最近的进展，我们的理解组织特异性T细胞的运输和如何调节T细胞运输的趋化因子系统有助于过敏性炎症小鼠模型和人类过敏性疾病的皮肤，肺和肠道。炎症和组织特异性T淋巴细胞运输途径目前被靶向作为非过敏性炎症性疾病的新疗法，并可能产生有效的过敏性疾病的新疗法。
Allergic inflammation develops in tissues that have large epithelial surface areas that are exposed to the environment, such as the lung, skin and gut. In the steady state, antigen-experienced memory T cells patrol these peripheral tissues to facilitate swift immune responses against invading pathogens. In at least two allergy-prone organs, the skin and the gut, memory T cells are programmed during the initial antigen priming to express trafficking receptors that enable them to preferentially home to these organs. In this review we propose that tissue-specific memory and inflammation-specific T cell trafficking facilitates the development of allergic disease in these organs. We thus review recent advances in our understanding of tissue-specific T cell trafficking and how regulation of T cell trafficking by the chemokine system contributes to allergic inflammation in mouse models and in human allergic diseases of the skin, lung and gut. Inflammation- and tissue-specific T lymphocyte trafficking pathways are currently being targeted as new treatments for non-allergic inflammatory diseases and may yield effective new therapeutics for allergic diseases.
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影响因子：
82.9
作者：
Conrad, Curdin;Boyman, Onur;Nestle, Frank O.
通讯作者：
Nestle, Frank O.
DOI：
10.1111/j.1749-6632.2003.tb06057.x
发表时间：
2003-01-01
期刊：
IMMUNE MECHANISMS AND DISEASE
影响因子：
--
作者：
Adorini, L
通讯作者：
Adorini, L
影响因子：
3.5
作者：
Abe, H;Takeshita, T;Sugamura, K
通讯作者：
Sugamura, K
影响因子：
4.4
作者：
Campbell, JJ;Brightling, CE;Wardlaw, AJ
通讯作者：
Wardlaw, AJ
DOI：
10.1084/jem.190.12.1755
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Charbonnier AS;Kohrgruber N;Kriehuber E;Stingl G;Rot A;Maurer D
通讯作者：
Maurer D