Effect of Adolescent Bariatric Surgery on the Brain and Cognition: A Pilot Study.
Effect of Adolescent Bariatric Surgery on the Brain and Cognition: A Pilot Study.
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DOI：
10.1002/oby.22013
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Vaidya CJ
中科院分区：
文献类型：
--
作者：
Pearce AL;Mackey E;Cherry JBC;Olson A;You X;Magge SN;Mietus-Snyder M;Nadler EP;Vaidya CJ
儿童肥胖症的神经认知缺陷与发育不良有关。我们寻找与青少年相对于等待名单（WL）和健康（HC）对照组的垂直袖状胃切除术（VSG）后致肥胖行为相关的大脑和认知功能变化的初步证据。36名青少年接受了两次功能磁共振成像4个月，在执行，奖励和情景记忆编码，除了奖励相关的决策行为测试。VSG青少年体重减轻，而WL体重增加，HC在两个时间点之间没有变化。在执行和奖励相关的性能增益更大的VSG比对照组。N-back期间左前额皮质中的组x时间相互作用（p <0.05校正）显示出与HC水平相当的更大的术前激活和术后减少，但时间点之间的WL增加。同样，左纹状体参数反应的奖励值手术后降低到HC水平，WL没有变化。记忆相关的内侧颞叶激活没有改变任何组。研究结果为VSG在重度肥胖青少年中引起的脑功能变化提供了初步证据。体重减轻和体重增加分别被减少和增加的前额叶激活所抑制，这表明神经可塑性与代谢变化有关。
Neurocognitive deficits in pediatric obesity relate to poor developmental outcomes. We sought preliminary evidence for changes in brain and cognitive functioning relevant to obesogenic behavior following vertical sleeve gastrectomy (VSG) in adolescents relative to wait-listed (WL) and healthy (HC) controls. Thirty-six adolescents underwent fMRI twice 4 months apart, during executive, reward, and episodic memory encoding, in addition to behavioral testing for reward-related decision making. VSG adolescents lost weight, while WL gained weight and HC did not change between timepoints. Gains in executive and reward-related performance were larger in VSG than control groups. Group x Time interaction (p <0.05 corrected) in left prefrontal cortex during N-back showed greater pre-surgical activation and post-surgical reduction comparable to HC levels, but increased in WL between timepoints. Similarly, left striatal parametric response to reward value reduced after surgery to HC levels; WL did not change. Memory-related medial temporal activation did not change in any group. Results provide pilot evidence for functional brain changes induced by VSG in adolescents with severe obesity. Weight loss and gain was paralleled by reduced and increased prefrontal activation, respectively, suggesting neural plasticity related to metabolic change.
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DOI：
10.1056/nejmoa1506699
发表时间：
2016-01-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inge TH;Courcoulas AP;Jenkins TM;Michalsky MP;Helmrath MA;Brandt ML;Harmon CM;Zeller MH;Chen MK;Xanthakos SA;Horlick M;Buncher CR;Teen-LABS Consortium
通讯作者：
Teen-LABS Consortium
影响因子：
3.3
作者：
Reinert KR;Po'e EK;Barkin SL
通讯作者：
Barkin SL
影响因子：
4.8
作者：
Owen, AM;McMillan, KM;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
4.9
作者：
Puder, J. J.;Munsch, S.
通讯作者：
Munsch, S.
影响因子：
4.9
作者：
Frank, S.;Wilms, B.;Schultes, B.
通讯作者：
Schultes, B.