Preliminary in vivo atherosclerotic carotid plaque characterization using the accumulated axial strain and relative lateral shift strain indices.
Preliminary in vivo atherosclerotic carotid plaque characterization using the accumulated axial strain and relative lateral shift strain indices.
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DOI：
10.1088/0031-9155/53/22/008
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发表时间：
2008-11-21
影响因子：
3.5
通讯作者：
Varghese T
中科院分区：
文献类型：
--
作者：
Shi H;Mitchell CC;McCormick M;Kliewer MA;Dempsey RJ;Varghese T
本文探讨了在活体临床超声成像条件下与斑块变形有关的两个参数或应变指数，即斑块内的最大累积轴向应变和斑块与血管壁之间的相对侧向位移，以可能识别易损斑块。利用基于斑块硬度和流动性的新视角，这些应变指数能够区分钙化斑块组织和脂质斑块组织。此外，它们还提供了区分较软的斑块的能力，与较硬的斑块组织相比，这些斑块在心脏周期中经历了较大的变形。在心脏周期内发生大变形的软斑块更容易破裂，并将微小栓子释放到脑血流中。识别容易破裂的易损斑块的能力，将显著提高这种方法在筛查患者方面的临床实用性。我们介绍了从16名动脉粥样硬化斑块患者接受颈动脉内膜切除术前收集的超声射频数据中获得的初步体内结果。我们在体内的初步结果表明，在一个心脏周期内的最大累积轴向应变和斑块的最大相对侧移或位移是区分软斑块和钙化斑块的有用的应变指标。
In this paper, we explore two parameters or strain indices related to plaque deformation during the cardiac cycle, namely, the maximum accumulated axial strain in plaque and the relative lateral shifts between plaque and vessel wall under in vivo clinical ultrasound imaging conditions for possible identification of vulnerable plaque. These strain indices enable differentiation between calcified and lipidic plaque tissue utilizing a new perspective based on the stiffness and mobility of the plaque. In addition, they also provide the ability to distinguish between softer plaques that undergo large deformations during the cardiac cycle when compared to stiffer plaque tissue. Soft plaques that undergo large deformations over the cardiac cycle are more prone to rupture and to release micro-emboli into the cerebral bloodstream. The ability to identify vulnerable plaque, prone to rupture, would significantly enhance the clinical utility of this method for screening patients. We present preliminary in vivo results obtained from ultrasound radio frequency data collected over 16 atherosclerotic plaque patients before these patients undergo a carotid endarterectomy procedure. Our preliminary in vivo results indicate that the maximum accumulated axial strain over a cardiac cycle and the maximum relative lateral shift or displacement of the plaque are useful strain indices that provide differentiation between soft and calcified plaques.
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影响因子：
2.9
作者：
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通讯作者：
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DOI：
10.1152/ajpheart.00988.2005
发表时间：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1109/tuffc.2006.1665075
发表时间：
2006-07-01
影响因子：
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作者：
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通讯作者：
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