Harnessing Tumor Evolution to Circumvent Resistance.
Harnessing Tumor Evolution to Circumvent Resistance.
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DOI：
10.1016/j.tig.2018.05.007
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Curtis C
中科院分区：
文献类型：
--
作者：
Pogrebniak KL;Curtis C
高通量测序可以用来测量肿瘤成分在空间和时间上的变化。具体地说，对治疗前后的样本进行比较可以揭示潜在的克隆动力学和耐药机制。在这里，我们讨论不同的肿瘤进化模式的证据及其对治疗策略的影响。此外，我们还考虑了空间组织采样方案、单细胞分析和循环肿瘤DNA来跟踪肿瘤进化和耐药性的出现，以及通过靶向肿瘤进化来预防耐药性的方法。最终，肿瘤进展过程中发生的(表观)基因组、转录和表型变化的特征，加上对肿瘤进化动力学的计算和数学建模，可能会为个性化的治疗策略提供信息。
High-throughput sequencing can be used to measure changes in tumor composition across space and time. Specifically, comparisons of pre- and post-treatment samples can reveal the underlying clonal dynamics and resistance mechanisms. Here, we discuss evidence for distinct modes of tumor evolution and their implications for therapeutic strategies. Additionally, we consider the utility of spatial tissue sampling schemes, single cell analysis, and circulating tumor DNA to track tumor evolution and the emergence of resistance, as well as approaches that seek to forestall resistance by targeting tumor evolution. Ultimately, characterization of the (epi)genomic, transcriptomic, and phenotypic changes that occur during tumor progression, coupled with computational and mathematical modeling of tumor evolutionary dynamics may inform personalized treatment strategies.
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DOI：
10.1146/annurev-cancerbio-042716-094839
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CANCER BIOLOGY, VOL 1
影响因子：
--
作者：
Bozic, Ivana;Nowak, Martin A.
通讯作者：
Nowak, Martin A.
影响因子：
7.7
作者：
Bozic I;Reiter JG;Allen B;Antal T;Chatterjee K;Shah P;Moon YS;Yaqubie A;Kelly N;Le DT;Lipson EJ;Chapman PB;Diaz LA Jr;Vogelstein B;Nowak MA
通讯作者：
Nowak MA
影响因子：
64.8
作者：
Abbosh C;Birkbak NJ;Wilson GA;Jamal-Hanjani M;Constantin T;Salari R;Le Quesne J;Moore DA;Veeriah S;Rosenthal R;Marafioti T;Kirkizlar E;Watkins TBK;McGranahan N;Ward S;Martinson L;Riley J;Fraioli F;Al Bakir M;Grönroos E;Zambrana F;Endozo R;Bi WL;Fennessy FM;Sponer N;Johnson D;Laycock J;Shafi S;Czyzewska-Khan J;Rowan A;Chambers T;Matthews N;Turajlic S;Hiley C;Lee SM;Forster MD;Ahmad T;Falzon M;Borg E;Lawrence D;Hayward M;Kolvekar S;Panagiotopoulos N;Janes SM;Thakrar R;Ahmed A;Blackhall F;Summers Y;Hafez D;Naik A;Ganguly A;Kareht S;Shah R;Joseph L;Marie Quinn A;Crosbie PA;Naidu B;Middleton G;Langman G;Trotter S;Nicolson M;Remmen H;Kerr K;Chetty M;Gomersall L;Fennell DA;Nakas A;Rathinam S;Anand G;Khan S;Russell P;Ezhil V;Ismail B;Irvin-Sellers M;Prakash V;Lester JF;Kornaszewska M;Attanoos R;Adams H;Davies H;Oukrif D;Akarca AU;Hartley JA;Lowe HL;Lock S;Iles N;Bell H;Ngai Y;Elgar G;Szallasi Z;Schwarz RF;Herrero J;Stewart A;Quezada SA;Peggs KS;Van Loo P;Dive C;Lin CJ;Rabinowitz M;Aerts HJWL;Hackshaw A;Shaw JA;Zimmermann BG;TRACERx consortium;PEACE consortium;Swanton C
通讯作者：
Swanton C
影响因子：
30.8
作者：
Gao, Ruli;Davis, Alexander;McDonald, Thomas O.;Sei, Emi;Shi, Xiuqing;Wang, Yong;Tsai, Pei-Ching;Casasent, Anna;Waters, Jill;Zhang, Hong;Meric-Bernstam, Funda;Michor, Franziska;Navin, Nicholas E.
通讯作者：
Navin, Nicholas E.
慢性淋巴细胞白血病患者对 BTK 抑制产生耐药性的克隆进化
影响因子：
16.6
作者：
Burger JA;Landau DA;Taylor-Weiner A;Bozic I;Zhang H;Sarosiek K;Wang L;Stewart C;Fan J;Hoellenriegel J;Sivina M;Dubuc AM;Fraser C;Han Y;Li S;Livak KJ;Zou L;Wan Y;Konoplev S;Sougnez C;Brown JR;Abruzzo LV;Carter SL;Keating MJ;Davids MS;Wierda WG;Cibulskis K;Zenz T;Werner L;Dal Cin P;Kharchencko P;Neuberg D;Kantarjian H;Lander E;Gabriel S;O'Brien S;Letai A;Weitz DA;Nowak MA;Getz G;Wu CJ
通讯作者：
Wu CJ