Uric acid and the origins of hypertension.
Uric acid and the origins of hypertension.
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DOI：
10.1016/j.jpeds.2012.12.078
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Johnson RJ
中科院分区：
文献类型：
--
作者：
Feig DI;Madero M;Jalal DI;Sanchez-Lozada LG;Johnson RJ
世纪见证了美国肥胖、高血压和糖尿病频率的爆炸性增长，分别影响了34%、29%和12%的成年人口（1-3）。儿童和青少年也不能幸免于这一流行病，儿童肥胖症的显著增加伴随着这一年龄组曾经罕见的疾病的显著增加，如原发性高血压，“成人发病”的2型糖尿病，代谢综合征和非酒精性脂肪性肝病（NAFLD），虽然儿童期高血压和2型糖尿病的出现令人担忧，但它为那些对疾病起源感兴趣的人提供了一个独特的机会。导致疾病发展的持续时间短，病情仍然相对罕见，儿科人群中其他合并症的数量减少，为更好地定义风险因素和病理生理学提供了机会。高血压的病因极有可能首先在儿童中确定，并且旨在有效预防或基于机制的治疗的第一批治疗也将涉及儿童。在这篇文章中，我们回顾了旨在确定高血压在这一流行病的病因的研究。我们将关注尿酸作为“黑马”，它正迅速成为驱动高血压的主要竞争者。
The twentieth century witnessed an explosive increase in the frequency of obesity, hypertension and diabetes in the US, affecting 34%, 29%, and 12% of the adult population, respectively (1–3). Children and adolescents were not immune to this epidemic, and the marked rise in obesity in children has been accompanied by marked increases in conditions that were once rare in this age-group, such as primary hypertension,“adult-onset” type 2 diabetes, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD), and even premature cardiovascular disease (4–6).While the emergence of hypertension and type 2 diabetes in childhood is alarming, it provides a unique opportunity for those interested in origins of disease. The short duration leading to the development of the disease, the still relative infrequency of the condition, and the reduced number of other comorbidities in the pediatric population provides an opportunity to better define risk factors and pathophysiology. It seems highly likely that the etiology of hypertension will be first identified in children, and that the first treatments aimed at effective prevention or mechanism-based cure will also involve children. In this article, we review studies that aim to identify the etiology of hypertension in this epidemic. We will focus on uric acid as the “dark horse” that is rapidly becoming a major contender for driving hypertension.
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影响因子：
158.5
作者：
CANNON, PJ;STASON, WB;LARAGH, JH
通讯作者：
LARAGH, JH
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
9.8
作者：
Clausen, T;Slott, M;Henriksen, T
通讯作者：
Henriksen, T
影响因子：
3.3
作者：
Danaei G;Friedman AB;Oza S;Murray CJ;Ezzati M
通讯作者：
Ezzati M
影响因子：
9.6
作者：
BECKER, BF;REINHOLZ, N;GERLACH, E
通讯作者：
GERLACH, E