Tumor targeting via EPR: Strategies to enhance patient responses.
Tumor targeting via EPR: Strategies to enhance patient responses.
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DOI：
10.1016/j.addr.2018.07.007
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发表时间：
2018-05
影响因子：
16.1
通讯作者：
Lammers T
中科院分区：
文献类型：
--
作者：
Golombek SK;May JN;Theek B;Appold L;Drude N;Kiessling F;Lammers T
纳米药物的肿瘤蓄积依赖于增强的渗透性和滞留(EPR)效应。在过去的5-10年里，人们越来越认识到EPR介导的肿瘤靶向存在很大的个体间和个体内的异质性，这解释了评价纳米药物配方的临床试验的异质性结果。为了解决这种异质性，就像在肿瘤学药物开发的其他领域一样，我们必须从一刀切的肿瘤靶向方法转向可以用于个性化和改进纳米药物治疗的方法。为此，必须努力更好地理解EPR效应的本质、复杂性和异质性，并建立系统和策略来增强、结合、绕过和成像基于EPR的肿瘤靶向。在目前的手稿中，我们总结了探索这些策略的关键研究，并讨论了如何使用这些方法来提高患者的反应。
The tumor accumulation of nanomedicines relies on the enhanced permeability and retention (EPR) effect. In the last 5-10 years, it has been increasingly recognized that there is a large inter- and intra-individual heterogeneity in EPR-mediated tumor targeting, explaining the heterogeneous outcomes of clinical trials in which nanomedicine formulations have been evaluated. To address this heterogeneity, as in other areas of oncology drug development, we have to move away from a one-size-fits-all tumor targeting approach, towards methods that can be employed to individualize and improve nanomedicine treatments. To this end, efforts have to be invested in better understanding the nature, the complexity and the heterogeneity of the EPR effect, and in establishing systems and strategies to enhance, combine, bypass and image EPR-based tumor targeting. In the present manuscript, we summarize key studies in which these strategies are explored, and we discuss how these approaches can be employed to enhance patient responses.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
5.5
作者：
Conniot J;Silva JM;Fernandes JG;Silva LC;Gaspar R;Brocchini S;Florindo HF;Barata TS
通讯作者：
Barata TS
影响因子：
6.8
作者：
Cathcart, Jillian;Pulkoski-Gross, Ashleigh;Cao, Jian
通讯作者：
Cao, Jian
影响因子：
12.7
作者：
Caretti V;Sewing AC;Lagerweij T;Schellen P;Bugiani M;Jansen MH;van Vuurden DG;Navis AC;Horsman I;Vandertop WP;Noske DP;Wesseling P;Kaspers GJ;Nazarian J;Vogel H;Hulleman E;Monje M;Wurdinger T
通讯作者：
Wurdinger T
影响因子：
45.3
作者：
Cobleigh, MA;Vogel, CL;Slamon, DJ
通讯作者：
Slamon, DJ