COVID 19 disease independently predicted endothelial dysfunction measured by flow-mediated dilatation.
COVID 19 disease independently predicted endothelial dysfunction measured by flow-mediated dilatation.
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DOI：
10.1007/s10554-021-02356-3
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Çetin M
中科院分区：
文献类型：
--
作者：
Ergül E;Yılmaz AS;Öğütveren MM;Emlek N;Kostakoğlu U;Çetin M
COVID-19疾病的全身性影响在很大程度上仍不确定，需要通过进一步的试验加以审查。内皮功能障碍（ED）是大多数不良心血管事件的原因。血流介导扩张（FMD）是一种容易准确评估ED的方法。目的是通过测量COVID-19疾病后的口蹄疫来评估ED。诊断为COVID-19疾病的患者在出院两个月后被招募到医院。以性别和年龄相匹配的健康受试者为对照组。从每位参与者身上获得血液样本和口蹄疫测量值。所有受试者根据口蹄疫测量确定的ED的存在分为两组。比较两组的人口学特征和COVID-19疾病康复情况。本研究共纳入92例受试者，其中59例无ED， 33例有ED。ED（+）组患者年龄更大（p = 0.015），高血压发生率更高（p = 0.044）， ED（+）组患者COVID-19发病率更高（p = 0.009）。ED（+）组中性粒细胞计数（p = 0.047）和CRP （p = 0.036）升高，eGFR （p = 0.044）降低。在反向多变量回归分析中，COVID-19疾病[OR = 3.611, 95% CI 1.069 ~ 12.198, p = 0.039]和BMI [OR = 1.122, 95% CI 1.023 ~ 1.231, p = 0.015]是ED的独立预测因子，COVID-19疾病可能导致ED，而ED是心血管疾病的主要潜在因素。此外，COVID-19疾病可能会恶化现有的心血管疾病病程。在早期发现ED或通过新的治疗方式进行预防可以改善短期和长期的结果。
The systemic effects of COVID-19 disease are still largely uncertain and needs to be scrutinized with further trials. Endothelial dysfunction (ED) is responsible for the majority of adverse cardiovascular events. Flow-mediated dilation (FMD) is easily obtainable method to assess ED accurately. It is aimed to evaluate ED by measuring FMD following COVID-19 disease. Patients diagnosed with COVID-19 disease were recruited to the hospital two month after the discharge. Sex and age-matched healthy subjects were determined as the control group. Blood samples and FMD measurements were obtained from each participant. All subjects were divided into two groups according to the presence of ED determined by FMD measurements. These two groups were compared in terms of demographic features and the presence of recovered COVID-19 disease. A total of 92 subjects consisting of 59 without ED and 33 with ED were included in the study. ED (+) group was older (p = 0.015) and more likely to have hypertension (p = 0.044) and COVID-19 rate was higher in ED (+) group (p = 0.009). While neutrophil count (p = 0.047) and CRP (p = 0.036) were higher, eGFR (p = 0.044) was lower in ED (+) group. In the backward multivariable regression analysis, COVID-19 disease [OR = 3.611, 95% CI 1.069–12.198, p = 0.039] and BMI [OR = 1.122, 95% CI 1.023–1.231, p = 0.015] were independent predictors of ED. COVID-19 disease may cause ED which is the major underlying factor of cardiovascular diseases. Furthermore, COVID-19 disease may deteriorate the existing cardiovascular disease course. Detecting ED in the early phase or preventing by new treatment modalities may improve short and long-term outcome.
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影响因子：
5.3
作者：
Nägele MP;Haubner B;Tanner FC;Ruschitzka F;Flammer AJ
通讯作者：
Flammer AJ
影响因子：
0.9
作者：
Penha D;Pinto EG;Matos F;Hochhegger B;Monaghan C;Taborda-Barata L;Irion K;Marchiori E
通讯作者：
Marchiori E
DOI：
10.5543/tkda.2020.36713
发表时间：
2020-05-01
期刊：
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
影响因子：
--
作者：
Aktoz, Meryem;Altay, Hakan;Yildizeli, Bedrettin
通讯作者：
Yildizeli, Bedrettin
影响因子：
3.4
作者：
Raitakari, OT;Celermajer, DS
通讯作者：
Celermajer, DS
DOI：
10.1007/978-3-319-57613-8_4
发表时间：
2017-01-01
期刊：
IMMUNOLOGY OF CARDIOVASCULAR HOMEOSTASIS AND PATHOLOGY
影响因子：
--
作者：
Sturtzel, Caterina
通讯作者：
Sturtzel, Caterina