Anatomical plasticity in the adult zebra finch song system.
Anatomical plasticity in the adult zebra finch song system.
复制标题
DOI：
10.1002/cne.23120
复制
发表时间：
2012-11-01
影响因子：
2.5
通讯作者：
Kirn, John R.
中科院分区：
文献类型：
--
作者：
McDonald, Kathryn S.;Kirn, John R.
在许多鸣禽中，与发声学习相关的细胞可塑性被认为在发育关键期后结束。然而，在斑胸草雀这样的物种中，越来越多的证据表明，鸣叫学习过程中常见的可塑性形式会持续到成年期，包括依赖听觉反馈来维持鸣叫。这种依赖随着年龄的增长而减弱，同时随着年龄相关的精细运动控制能力的增强。我们通过关注两种皮层投射神经元类型，研究了成年斑胸草雀鸣叫系统中与年龄相关的形态变化，这两种类型a）共享共同的传出目标，b）已知在鸣叫学习过程中表现出形态和功能变化，c）对鸣叫声学结构产生相反的影响。 HVC（专有名称）和前巢皮质外侧大细胞核 (LMAN) 中的神经元都投射到坚固的弓状皮质核 (RA)。在青少年歌曲学习和成人歌曲维持过程中，HVC 促进歌曲音节刻板，而 LMAN 促进学习和声学变异。在成人中对这两种细胞类型进行逆行标记后，HVC-RA 神经元中的树突状乔木出现了与年龄相关的增加，但 LMAN-RA 神经元中的树突状乔木没有增加，导致 HVC-RA:LMAN-RA 树突状乔木的比例增加。 HVC 相对于 LMAN 树突的差异生长可能与歌曲运动精细化的增加、歌曲对听觉反馈的依赖的减少或两者有关。尽管随着年龄的增长存在差异，但我们还表明，这两种细胞类型都保留了依赖经验的生长能力。这些结果可能为促进和限制成人声音可塑性的机制提供见解。
In many songbirds, vocal learning-related cellular plasticity was thought to end following a developmental critical period. However, mounting evidence in one such species, the zebra finch, suggests that forms of plasticity common during song learning continue well into adulthood, including a reliance on auditory feedback for song maintenance. This reliance wanes with increasing age, in tandem with age-related increases in fine motor control. We investigated age-related morphological changes in the adult zebra finch song system by focusing on two cortical projection neuron types that a) share a common efferent target, b) are known to exhibit morphological and functional change during song learning, and c) exert opposing influences on song acoustic structure. Neurons in HVC (proper name) and the lateral magnocellular nucleus of the anterior nidopallium (LMAN) both project to the robust nucleus of the arcopallium (RA). During juvenile song learning and adult song maintenance, HVC promotes song syllable stereotypy while LMAN promotes learning and acoustic variability. Following retrograde labeling of these two cell types in adults, there were age-related increases in dendritic arbor in HVC-RA but not LMAN-RA neurons, resulting in an increase in the ratio of HVC-RA:LMAN-RA dendritic arbor. Differential growth of HVC relative to LMAN dendrites may relate to increases in song motor refinement, decreases in the reliance of song on auditory feedback, or both. Despite this differential growth with age, we also show that both cell types retain the capacity for experience-dependent growth. These results may provide insights on mechanisms that promote and constrain adult vocal plasticity.
登录
查看更多内容
影响因子：
2.5
作者：
Brusco, Janaina;Wittmann, Raul;Rasia-Filho, Alberto A.
通讯作者：
Rasia-Filho, Alberto A.
影响因子：
1.3
作者：
Dunn, AM;Zann, RA
通讯作者：
Zann, RA
影响因子：
2.5
作者：
BOTTJER, SW;HALSEMA, KA;MIESNER, EA
通讯作者：
MIESNER, EA
影响因子：
56.9
作者：
Aronov, Dmitriy;Andalman, Aaron S.;Fee, Michale S.
通讯作者：
Fee, Michale S.
影响因子：
1.7
作者：
Hurley, Patrick;Pytte, Carolyn;Kirn, John R.
通讯作者：
Kirn, John R.