Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension.
Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension.
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DOI：
10.1038/s41598-020-77349-8
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发表时间：
2020-11-26
影响因子：
4.6
通讯作者：
Hakamata Y
中科院分区：
文献类型：
--
作者：
Sugai K;Tamura T;Sano M;Uemura S;Fujisawa M;Katsumata Y;Endo J;Yoshizawa J;Homma K;Suzuki M;Kobayashi E;Sasaki J;Hakamata Y
最近的一项临床研究表明，使用含氢气 (H2) 的透析液进行血液透析可以改善终末期肾病的血压控制。在此，我们在动物模型中研究了 H2 是否对高血压有有益作用。我们让 5/6 肾切除大鼠每天吸入 H2（1.3% H2 + 21% O2 + 77.7% N2）或对照（21% O2 + 79% N2）气体混合物 1 小时。 H2 显着抑制 5/6 肾切除术后血压的升高。 H2 的抗高血压作用也在肾切除术后 3 周处于稳定高血压状态的大鼠中得到证实。为了检查氢气对高血压的详细影响，我们使用植入式遥测系统来连续监测血压。 H2不仅在白天休息时发挥抗高血压作用，而且在夜间活动时也发挥作用。血压变异性的频谱分析表明，H2 可改善自主神经失衡，即通过抑制过度活跃的交感神经系统并增强副交感神经系统的活动；这些作用与降血压作用同时发生。总之，每天接触 H2 1 小时可在高血压动物模型中发挥抗高血压作用。
A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.
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DOI：
10.1152/ajpheart.00619.2003
发表时间：
2004-08-01
影响因子：
4.8
作者：
Campese, VM;Ye, SH;Chiu, J
通讯作者：
Chiu, J
DOI：
10.1016/j.bbrc.2008.05.165
发表时间：
2008-08-15
影响因子：
3.1
作者：
Hayashida, Kentaro;Sano, Motoaki;Fukuda, Keiichi
通讯作者：
Fukuda, Keiichi
影响因子：
3.7
作者：
Kobayashi, Eiji;Sano, Motoaki
通讯作者：
Sano, Motoaki
影响因子：
8.3
作者：
CAMPESE, VM;KOGOSOV, E
通讯作者：
KOGOSOV, E
影响因子：
3.3
作者：
Katsumata, Yoshinori;Sano, Fumiya;Sano, Motoaki
通讯作者：
Sano, Motoaki