Robust thalamic nuclei segmentation method based on local diffusion magnetic resonance properties.
Robust thalamic nuclei segmentation method based on local diffusion magnetic resonance properties.
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DOI：
10.1007/s00429-016-1336-4
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发表时间：
2017-07
影响因子：
3.1
通讯作者：
Fornari E
中科院分区：
文献类型：
--
作者：
Battistella G;Najdenovska E;Maeder P;Ghazaleh N;Daducci A;Thiran JP;Jacquemont S;Tuleasca C;Levivier M;Bach Cuadra M;Fornari E
丘脑是皮质-皮质下联系的重要中继站。其特征在于由许多小核团组成的复杂解剖结构，这些小核团介导丘脑参与广泛的神经功能。我们提出了一个新的框架分割丘脑核，探讨方向分布函数（ODF）在3 T的扩散磁共振图像。通过使用ODF的球谐（SH）表示，它提供了每个体素中的扩散过程的全角度表征，改善了复杂的丘脑内微结构的分化。使用以数据驱动方式初始化的k-means算法进行聚类。该方法进行了测试，对35名健康志愿者，我们的结果显示了一个强大的，可重复的和准确的分割丘脑在7个核团。其中6个与解剖结构密切匹配，并被标记为前，腹前，中背，腹侧腹侧，腹侧背侧和枕，而第七簇包括中央外侧和侧后核。通过比较分割的细胞核与Morel的组织学图谱，对结果进行定性评价，并通过测量集群的范围和集群在受试者和半球之间的空间分布，对结果进行定量评价。我们还展示了我们的方法在不同序列和扫描仪上的鲁棒性，以及使用额外的两个扫描重新扫描数据集的分割簇的受试者内再现性。我们还观察到通过丘脑的主要长连接束的路径与我们的聚类算法确定的核的空间分布之间的重叠。我们的方法，基于SH表示的ODF，优于一个基于主扩散方向之间的角度差，这被认为是迄今为止的国家的最先进的方法。我们的研究结果表明，解剖学上可靠的分割丘脑核的主要群体，可能是潜在的使用在许多临床应用。本文的在线版本（doi：10.1007/s 00429 -016-1336-4）包含补充材料，可供授权用户使用。
The thalamus is an essential relay station in the cortical–subcortical connections. It is characterized by a complex anatomical architecture composed of numerous small nuclei, which mediate the involvement of the thalamus in a wide range of neurological functions. We present a novel framework for segmenting the thalamic nuclei, which explores the orientation distribution functions (ODFs) from diffusion magnetic resonance images at 3 T. The differentiation of the complex intra-thalamic microstructure is improved by using the spherical harmonic (SH) representation of the ODFs, which provides full angular characterization of the diffusion process in each voxel. The clustering was performed using the k-means algorithm initialized in a data-driven manner. The method was tested on 35 healthy volunteers and our results show a robust, reproducible and accurate segmentation of the thalamus in seven nuclei groups. Six of them closely matched the anatomy and were labeled as anterior, ventral anterior, medio-dorsal, ventral latero-ventral, ventral latero-dorsal and pulvinar, while the seventh cluster included the centro-lateral and the latero-posterior nuclei. Results were evaluated both qualitatively, by comparing the segmented nuclei to the histological atlas of Morel, and quantitatively, by measuring the clusters’ extent and the clusters’ spatial distribution across subjects and hemispheres. We also showed the robustness of our approach across different sequences and scanners, as well as intra-subject reproducibility of the segmented clusters using additional two scan–rescan datasets. We also observed an overlap between the path of the main long-connection tracts passing through the thalamus and the spatial distribution of the nuclei identified with our clustering algorithm. Our approach, based on SH representations of the ODFs, outperforms the one based on angular differences between the principle diffusion directions, which is considered so far as state-of-the-art method. Our findings show an anatomically reliable segmentation of the main groups of thalamic nuclei that could be of potential use in many clinical applications. The online version of this article (doi:10.1007/s00429-016-1336-4) contains supplementary material, which is available to authorized users.
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影响因子：
5.7
作者：
O'Muircheartaigh J;Vollmar C;Traynor C;Barker GJ;Kumari V;Symms MR;Thompson P;Duncan JS;Koepp MJ;Richardson MP
通讯作者：
Richardson MP
影响因子：
5.7
作者：
Magnotta, VA;Gold, S;Yuh, WTC
通讯作者：
Yuh, WTC
影响因子：
1.4
作者：
Gut, Malgorzata;Urbanik, Andrzej;Grabowska, Anna
通讯作者：
Grabowska, Anna
DOI：
10.1073/pnas.0403743101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
通讯作者：
Matthews, PM
DOI：
10.1002/cnm.1630040306
发表时间：
1988-05-01
期刊：
COMMUNICATIONS IN APPLIED NUMERICAL METHODS
影响因子：
--
作者：
CORDOVA, JQ;PEARSON, CE
通讯作者：
PEARSON, CE