Gamma oscillatory amplitude encodes stimulus intensity in primary somatosensory cortex.
Gamma oscillatory amplitude encodes stimulus intensity in primary somatosensory cortex.
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DOI：
10.3389/fnhum.2013.00362
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发表时间：
2013
影响因子：
2.9
通讯作者：
Furlong PL
中科院分区：
文献类型：
--
作者：
Rossiter HE;Worthen SF;Witton C;Hall SD;Furlong PL
伽玛振荡以前被认为与疼痛感知有关，并被假设它们可能在编码疼痛强度方面具有潜在作用。刺激反应实验已经报道，初级躯体感觉皮层(SI)的活动随着刺激强度的增加而增加，但振荡动力学在这种激活变化中的具体作用尚不清楚。在这项研究中，使用脑磁图(MEG)研究了四种不同强度的电刺激对右食指电刺激时，从轻微感觉到强烈疼痛的皮层振荡的变化。在那些在刺激期间SI中表现出诱发振荡伽马变化的参与者中，发现伽马功率的强度在疼痛和亚疼痛阈值下都随着刺激强度的增加而增加。这些结果表明，SI中诱发的伽马振荡不是疼痛所特有的，但可能在编码体感刺激强度方面起作用。
Gamma oscillations have previously been linked to pain perception and it has been hypothesized that they may have a potential role in encoding pain intensity. Stimulus response experiments have reported an increase in activity in the primary somatosensory cortex (SI) with increasing stimulus intensity, but the specific role of oscillatory dynamics in this change in activation remains unclear. In this study, Magnetoencephalography (MEG) was used to investigate the changes in cortical oscillations during four different intensities of a train of electrical stimuli to the right index finger, ranging from low sensation to strong pain. In those participants showing changes in evoked oscillatory gamma in SI during stimulation, the strength of the gamma power was found to increase with increasing stimulus intensity at both pain and sub-pain thresholds. These results suggest that evoked gamma oscillations in SI are not specific to pain but may have a role in encoding somatosensory stimulus intensity.
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