TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO2-Drive to Breathe
TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO2-Drive to Breathe
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TRPV1 抑制成年大鼠对缺氧的通气反应，但不抑制二氧化碳驱动的呼吸
DOI：
10.3390/ph12010019
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发表时间：
2019
期刊：
影响因子：
4.6
通讯作者：
L. Gargaglioni
中科院分区：
文献类型：
--
作者：
L. Patrone;Jaime B. Duarte;K. Bícego;A. Steiner;A. A. Romanovsky;L. Gargaglioni
瞬时受体电位（TRP）通道超家族的受体在许多组织中表达，并具有不同的生理功能。然而，很少有研究调查这些通道在哺乳动物心肺控制中的作用。我们通过测量雄性 Wistar 大鼠腹膜内注射 (AMG9810 [2.85 µg/kg, 1 mL/kg]) 或脑室内注射前后的肺通气量 (V˙E)、心率 (HR)、平均动脉压 (MAP) 和体温 (Tb)，评估了中枢和外周 TRPV1 受体在缺氧 (10% O2) 和高碳酸血症 (7% CO2) 心肺反应中的作用。 （AMG9810 [2.85 µg/kg，1 µL] 或 AMG7905 [28.5 µg/kg，1 µL]）TRPV1 拮抗剂注射。在室内空气和高碳酸血症条件下，中枢或外周注射 TRPV1 拮抗剂不会改变心肺参数或 Tb。然而，中枢和外周注射 AMG9810 都会加剧缺氧通气反应。此外，外周拮抗剂可以减缓缺氧引起的 Tb 下降。因此，目前的数据提供证据表明 TRPV1 通道对缺氧呼吸驱动发挥抑制调节作用，并刺激缺氧期间 Tb 的减少。
Receptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O2) and hypercapnia (7% CO2) by measuring pulmonary ventilation (V˙E), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2.85 µg/kg, 1 mL/kg]) or intracebroventricular (AMG9810 [2.85 µg/kg, 1 µL] or AMG7905 [28.5 μg/kg, 1 µL]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia.
影响因子：
3.2
作者：
Kollarik, Marian;Ru, Fei;Undem, Bradley J.
通讯作者：
Undem, Bradley J.
DOI：
10.1016/j.molbrainres.2004.12.003
发表时间：
2005-04-27
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Tóth, A;Boczán, J;Blumberg, PM
通讯作者：
Blumberg, PM