Immunometabolic Changes in Glia - A Potential Role in the Pathophysiology of Obesity and Diabetes.
Immunometabolic Changes in Glia - A Potential Role in the Pathophysiology of Obesity and Diabetes.
复制标题
DOI：
10.1016/j.neuroscience.2019.10.021
复制
发表时间：
2020-11-01
期刊：
影响因子：
3.3
通讯作者：
Ellacott KLJ
中科院分区：
文献类型：
--
作者：
Robb JL;Morrissey NA;Weightman Potter PG;Smithers HE;Beall C;Ellacott KLJ
神经胶质细胞直接响应调节能量平衡的营养物质和激素的变化。小胶质细胞和星形胶质细胞与肥胖和糖尿病的病理生理学有关。肥胖导致神经胶质增生：神经胶质结构和功能的可逆变化。在代谢疾病中，炎症驱动的神经胶质变化可能调节神经元。控制能量平衡的神经回路的神经胶质调节需要更多的研究。慢性低度炎症是中枢神经系统以及周围组织中肥胖和糖尿病的病理生理学特征。神经胶质细胞是大脑炎症反应的关键介质。神经胶质细胞的主要特征包括其代谢灵活性、对中枢神经系统微环境变化的敏感性以及相应地快速调整其功能的能力。它们是专门的细胞，共同促进和维护神经元健康，在不同生命阶段调节大脑神经元网络的活动中发挥着重要作用。越来越多的证据表明，神经胶质细胞，尤其是星形胶质细胞和小胶质细胞，在正常生理控制过程和疾病期间的能量和葡萄糖稳态的系统调节中发挥着作用。炎症是一个消耗能量的过程，需要细胞代谢的适应性变化，反过来，代谢中间产物也可以具有免疫调节作用。外周免疫细胞的这种“免疫代谢”变化与肥胖和糖尿病的疾病病理有关。本综述将讨论神经胶质细胞的免疫代谢变化在能量和葡萄糖稳态的系统调节中的作用的证据，以及这种变化在肥胖和糖尿病的背景下如何变化。
Glia direct respond to changes in nutrients and hormones regulating energy balance. Microglia and astrocytes are implicated in the pathophysiology of obesity and diabetes. Obesity causes gliosis: reversible changes in glia structure and function. In metabolic disease inflammation-driven changes in glial likely regulates neurons. Glial regulation of neural circuits controlling energy balance requires more study. Chronic low-grade inflammation is a feature of the pathophysiology of obesity and diabetes in the CNS as well as peripheral tissues. Glial cells are critical mediators of the response to inflammation in the brain. Key features of glia include their metabolic flexibility, sensitivity to changes in the CNS microenvironment, and ability to rapidly adapt their function accordingly. They are specialised cells which cooperate to promote and preserve neuronal health, playing important roles in regulating the activity of neuronal networks across the brain during different life stages. Increasing evidence points to a role of glia, most notably astrocytes and microglia, in the systemic regulation of energy and glucose homeostasis in the course of normal physiological control and during disease. Inflammation is an energetically expensive process that requires adaptive changes in cellular metabolism and, in turn, metabolic intermediates can also have immunomodulatory actions. Such “immunometabolic” changes in peripheral immune cells have been implicated in contributing to disease pathology in obesity and diabetes. This review will discuss the evidence for a role of immunometabolic changes in glial cells in the systemic regulation of energy and glucose homeostasis, and how this changes in the context of obesity and diabetes.
登录
查看更多内容
影响因子：
8.1
作者：
Buckman LB;Thompson MM;Lippert RN;Blackwell TS;Yull FE;Ellacott KL
通讯作者：
Ellacott KL
影响因子：
16.2
作者：
Burda JE;Sofroniew MV
通讯作者：
Sofroniew MV
影响因子：
4.7
作者：
Bouyakdan, Khalil;Taib, Bouchra;Alquier, Thierry
通讯作者：
Alquier, Thierry
影响因子：
4.7
作者：
Belanger, Mireille;Allaman, Igor;Magistretti, Pierre J.
通讯作者：
Magistretti, Pierre J.
影响因子：
5.1
作者：
Churchward MA;Tchir DR;Todd KG
通讯作者：
Todd KG