Rhizoma Coptidis: A Potential Cardiovascular Protective Agent.
Rhizoma Coptidis: A Potential Cardiovascular Protective Agent.
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DOI：
10.3389/fphar.2016.00362
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发表时间：
2016
影响因子：
5.6
通讯作者：
Goh BH
中科院分区：
文献类型：
--
作者：
Tan HL;Chan KG;Pusparajah P;Duangjai A;Saokaew S;Mehmood Khan T;Lee LH;Goh BH
心血管疾病（CVD）是发达国家和发展中国家发病和死亡的主要原因之一。黄连（RC），在中国被称为黄连，是毛茛科药用植物的干燥根茎，如黄连、C. deltoidea C.Y. Cheng et Hsiao 和 C. teeta Wall 已被中医使用了 2000 多年。在中国，RC是用于治疗肥胖、糖尿病、高脂血症、高血糖和脂质代谢紊乱等心血管疾病相关问题的传统药物中的常见成分。近年来，大量科学研究试图调查RC的生物学特性，为其传统医学用途提供科学证据。研究发现RC对CVD的主要危险因素具有显着的有益作用，包括抗动脉粥样硬化作用、降脂作用、抗肥胖作用和抗肝脂肪变性作用。它还具有心肌保护作用，因为它可以防止心肌缺血再灌注损伤。这些特性归因于 RC 中含有的生物活性化合物，如小檗碱、黄连碱、巴马汀、表小檗碱、药根碱和木兰花碱；所有这些都已被证明对通过多种途径导致 CVD 发生的各种参数具有心脏保护作用。已发表文献中的证据表明，RC 是一种具有降低 CVD 风险的巨大潜力的草药，本综述旨在参考已发表的文献总结 RC 的心脏保护特性，总体表明 RC 是一种具有显着降低 CVD 风险和损害潜力的草药。
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality in both the developed and developing world. Rhizoma coptidis (RC), known as Huang Lian in China, is the dried rhizome of medicinal plants from the family Ranunculaceae, such as Coptis chinensis Franch, C. deltoidea C.Y. Cheng et Hsiao, and C. teeta Wall which has been used by Chinese medicinal physicians for more than 2000 years. In China, RC is a common component in traditional medicines used to treat CVD associated problems including obesity, diabetes mellitus, hyperlipidemia, hyperglycemia and disorders of lipid metabolism. In recent years, numerous scientific studies have sought to investigate the biological properties of RC to provide scientific evidence for its traditional medical uses. RC has been found to exert significant beneficial effects on major risk factors for CVDs including anti-atherosclerotic effect, lipid-lowering effect, anti-obesity effect and anti-hepatic steatosis effect. It also has myocardioprotective effect as it provides protection from myocardial ischemia-reperfusion injury. These properties have been attributed to the presence of bioactive compounds contained in RC such as berberine, coptisine, palmatine, epiberberine, jatrorrhizine, and magnoflorine; all of which have been demonstrated to have cardioprotective effects on the various parameters contributing to the occurrence of CVD through a variety of pathways. The evidence available in the published literature indicates that RC is a herb with tremendous potential to reduce the risks of CVDs, and this review aims to summarize the cardioprotective properties of RC with reference to the published literature which overall indicates that RC is a herb with remarkable potential to reduce the risks and damage caused by CVDs.
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