Jiao tai wan attenuates hepatic lipid accumulation in type 2 diabetes mellitus.
Jiao tai wan attenuates hepatic lipid accumulation in type 2 diabetes mellitus.
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DOI：
10.1155/2013/567045
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Xu L
中科院分区：
文献类型：
--
作者：
Huang Z;Xu X;Lu F;Wang N;Chen G;Zhao Y;Zou X;Wang K;Dong H;Xu L
交泰丸（JTW）是一种含有大黄和黄柏的中药配方，多年来一直用于治疗糖尿病。本研究的目的是确定JTW中的主要成分，并研究JTW对糖尿病大鼠和人类肝脏脂质蓄积的影响。采用高效液相色谱法测定其主要成分的含量。建立糖尿病动物模型，灌胃给药。在临床研究中，对血糖控制不佳的糖尿病患者进行了JTW治疗。检测血糖和血脂指标、肝脏组织学、肝脏甘油三酯含量和脂肪生成基因表达。结果表明，降糖丸能显著改善糖尿病大鼠高血糖、高血脂及肝脏脂质蓄积。肝组织中乙酰辅酶A羧化酶（ACC）和脂肪酸合成酶（FAS）蛋白表达下调，腺苷酸活化蛋白激酶（AMPK）和磷酸化ACC（pACC）蛋白表达上调。糖尿病患者的肝脏甘油三酯含量也有所下降。结果表明，JTW减弱糖尿病大鼠和人类的肝脏脂质积聚。这些有益作用可能与抑制肝脏中的脂肪生成基因表达有关。
Jiao Tai Wan (JTW), a Chinese herbal formula containing Rhizoma Coptidis and Cortex Cinnamomi, has been used for diabetic treatment for many years. The aim of this study was to determine the main components in JTW and to investigate the effects of JTW on hepatic lipid accumulation in diabetic rats and humans. JTW extract was prepared and the main components were assayed by HPLC. An animal model of diabetes mellitus was established and JTW was administered intragastrically. In the clinical study, diabetic patients with poor glycemic control were treated with JTW. Blood glucose and lipid parameters, liver histology, hepatic triglyceride content and lipogenic gene expression were examined. Our data demonstrated that JTW significantly improved hyperglycemia, hyperlipidemia and hepatic lipid accumulation in diabetic rats. This was accompanied by the down-regulation of acetyl coenzyme A carboxylase (ACC) and fatty acid synthase (FAS) protein expressions, and the up-regulation of AMP-activated protein kinase (AMPK) and phosphorylated-ACC (pACC) protein expressions in the liver tissues. Diabetic patients also exhibited decreases in their hepatic triglyceride content. The results suggest that JTW attenuates hepatic lipid accumulation in diabetic rats and humans. These beneficial effects are possibly associated with the inhibition of lipogenic gene expression in the liver.
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DOI：
10.1016/j.ecl.2008.09.002
发表时间：
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影响因子：
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作者：
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