Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes.
Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes.
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Vaticaffinol 是白藜芦醇四聚体，在体外和体内通过多个方面针对活化的 T 淋巴细胞发挥比其前体更好的免疫抑制活性。
DOI：
10.1016/j.taap.2012.12.017
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
LL Feng, XF Wu, HL Liu, WJ Guo, Q Luo, FF Tao, Y
中科院分区：
文献类型：
--
作者：
LL Feng, XF Wu, HL Liu, WJ Guo, Q Luo, FF Tao, Y
本研究旨在研究白藜芦醇四聚体Vaticaffinol在体内外对T淋巴细胞的免疫抑制作用，并进一步探讨其可能的分子机制。白藜芦醇具有广泛的健康益处，具有多个靶点。有趣的是，它的四聚体--维生素A醇比白藜芦醇具有更强的免疫抑制活性。青蒿素显著抑制刀豆蛋白A(ConA)或抗CD3+抗CD28诱导的T细胞增殖，呈剂量和时间依赖关系。它还通过线粒体途径诱导ConA激活的T细胞发生凋亡。此外，该化合物还能阻止T细胞在活化过程中进入S期和G2/M期。此外，Vaticaffinol抑制ConA激活的T细胞中的ERK和AKT信号通路。此外，在体内苦味酰氯诱导的耳接触性皮炎小鼠模型中，维生素Aphinol显著改善了耳肿胀。然而，在上述大多数实验中，白藜芦醇对T淋巴细胞的抑制作用与维生素Aphinol相比只有轻微的影响。综上所述，我们的研究结果表明，无论是在体外还是在体内，Vaticaffinol都比其前体白藜芦醇具有更好的免疫抑制活性，它通过影响多个靶点来对抗激活的T细胞。
In the present study, we aimed to investigate the immunosuppressive activity of vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, on T lymphocytes both in vitro and in vivo, and further explored its potential molecular mechanism. Resveratrol had a wide spectrum of healthy beneficial effects with multiple targets. Interestingly, its tetramer, vaticaffinol, exerted more intensive immunosuppressive activity than resveratrol. Vaticaffinol significantly inhibited T cells proliferation activated by concanavalin A (Con A) or anti-CD3 plus anti-CD28 in a dose- and time-dependent manner. It also induced Con A-activated T cells undergoing apoptosis through mitochondrial pathway. Moreover, this compound prevented cells from entering S phase and G2/M phase during T cells activation. In addition, vaticaffinol inhibited ERK and AKT signaling pathways in Con A-activated T cells. Furthermore, vaticaffinol significantly ameliorated ear swelling in a mouse model of picryl chloride-induced ear contact dermatitis in vivo. In most of the aforementioned experiments, however, resveratrol had only slight effects on the inhibition of T lymphocytes compared with vaticaffinol. Taken together, our findings suggest that vaticaffinol exerts more preferable immunosuppressive activity than its precursor resveratrol both in vitro and in vivo by affecting multiple targets against activated T cells.
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