CoryneRegNet 6.0--Updated database content, new analysis methods and novel features focusing on community demands.
CoryneRegNet 6.0--Updated database content, new analysis methods and novel features focusing on community demands.
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DOI：
10.1093/nar/gkr883
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发表时间：
2012-01
影响因子：
14.9
通讯作者：
Baumbach J
中科院分区：
文献类型：
--
作者：
Pauling J;Röttger R;Tauch A;Azevedo V;Baumbach J
后基因组分析技术，如下一代测序，已经产生了大量关于微生物的数据，包括基因序列，它们的功能注释和基因调控相互作用。后者是控制细胞特性的遗传机制，例如致病性以及生存和繁殖策略。CoryneRegNet是棒状杆菌基因调控网络的参考数据库和分析平台。在这篇文章中，我们介绍了CoryneRegNet的更新版本6.0，并描述了更新后的数据库内容，其中包括，6352棒状杆菌的监管相互作用相比，4235在发布版本5.0和4.0的相互作用，分别。我们还展示了我们如何通过集成分析和可视化功能来支持社区瞬时导入的自定义数据，如基因调控相互作用。此外，在6.0版中，我们提供了易于使用的功能，允许用户提交数据以永久存储在CoryneRegNet数据库中。因此，它在社区需求方面为其用户提供了重要的选择。CoryneRegNet可在http://www.coryneregnet.de上公开获取。
Post-genomic analysis techniques such as next-generation sequencing have produced vast amounts of data about micro organisms including genetic sequences, their functional annotations and gene regulatory interactions. The latter are genetic mechanisms that control a cell's characteristics, for instance, pathogenicity as well as survival and reproduction strategies. CoryneRegNet is the reference database and analysis platform for corynebacterial gene regulatory networks. In this article we introduce the updated version 6.0 of CoryneRegNet and describe the updated database content which includes, 6352 corynebacterial regulatory interactions compared with 4928 interactions in release 5.0 and 3235 regulations in release 4.0, respectively. We also demonstrate how we support the community by integrating analysis and visualization features for transiently imported custom data, such as gene regulatory interactions. Furthermore, with release 6.0, we provide easy-to-use functions that allow the user to submit data for persistent storage with the CoryneRegNet database. Thus, it offers important options to its users in terms of community demands. CoryneRegNet is publicly available at http://www.coryneregnet.de.
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影响因子：
14.9
作者：
Krawczyk J;Kohl TA;Goesmann A;Kalinowski J;Baumbach J
通讯作者：
Baumbach J
影响因子：
5.8
作者：
Münch, R;Hiller, K;Jahn, D
通讯作者：
Jahn, D
影响因子：
14.9
作者：
Salgado, H;Santos-Zavaleta, A;Collado-Vides, J
通讯作者：
Collado-Vides, J
影响因子：
3
作者：
Baumbach J
通讯作者：
Baumbach J
影响因子：
14.8
作者：
Wittkop, Tobias;Emig, Dorothea;Baumbach, Jan
通讯作者：
Baumbach, Jan