Critical buckling pressure in mouse carotid arteries with altered elastic fibers.
Critical buckling pressure in mouse carotid arteries with altered elastic fibers.
复制标题
小鼠颈动脉的临界屈曲压力，弹性纤维改变。
DOI：
10.1016/j.jmbbm.2015.02.013
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发表时间：
2015-06
影响因子：
3.9
通讯作者：
Wagenseil, Jessica E.
中科院分区：
文献类型：
--
作者：
Luetkemeyer, Callan M.;James, Rhys H.;Deuarakonda, Siva Teja;Le, Victoria P.;Liu, Qin;Han, Hai-Chao;Wagenseil, Jessica E.
由于机械不稳定性，在施加临界屈曲压力下，动脉可轴向屈曲。屈曲可导致动脉迂曲，导致血流不规则和中风。弹性纤维蛋白的基因突变与人类和小鼠的动脉迂曲度有关，可能是临界屈曲压力改变的结果。因此，本研究的目的是调查如何在弹性纤维的遗传缺陷影响屈曲压力。我们使用人类疾病的小鼠模型，其中弹性蛋白（Eln+/−）的量减少，并且由于缺乏fibulin-5（Fbln 5 −/−）而导致弹性纤维组装缺陷。我们发现，与野生型对照相比，Eln+/−动脉的屈曲压力降低。Fbln 5 −/−动脉在低轴向拉伸下具有与野生型相似的屈曲压力，但在高拉伸下增加屈曲压力。我们使用Fung和四纤维应变能函数将材料参数与Eln+/-、Fbln 5-/-和野生型动脉的机械测试数据进行拟合。拟合参数用于预测理论屈曲压力的基础上平衡的充气，屈曲，厚壁圆筒。一般而言，理论预测低估了低轴向拉伸时的屈曲压力，而高估了高拉伸时的屈曲压力。两种模型的理论预测都复制了Fbln 5 −/−动脉在高拉伸下增加的屈曲压力，但四纤维模型预测最符合屈曲压力随轴向拉伸变化的实验趋势。这项研究为进一步研究弹性纤维基因突变对屈曲行为和动脉迂曲发展的影响提供了实验和理论方法。
Arteries can buckle axially under applied critical buckling pressure due to a mechanical instability. Buckling can cause arterial tortuosity leading to flow irregularities and stroke. Genetic mutations in elastic fiber proteins are associated with arterial tortuosity in humans and mice, and may be the result of alterations in critical buckling pressure. Hence, the objective of this study is to investigate how genetic defects in elastic fibers affect buckling pressure. We use mouse models of human disease with reduced amounts of elastin (Eln+/−) and with defects in elastic fiber assembly due to the absence of fibulin-5 (Fbln5−/−). We find that Eln+/− arteries have reduced buckling pressure compared to their wild-type controls. Fbln5−/− arteries have similar buckling pressure to wild-type at low axial stretch, but increased buckling pressure at high stretch. We fit material parameters to mechanical test data for Eln+/−, Fbln5−/− and wild-type arteries using Fung and four-fiber strain energy functions. Fitted parameters are used to predict theoretical buckling pressure based on equilibrium of an inflated, buckled, thick-walled cylinder. In general, the theoretical predictions underestimate the buckling pressure at low axial stretch and overestimate the buckling pressure at high stretch. The theoretical predictions with both models replicate the increased buckling pressure at high stretch for Fbln5−/− arteries, but the four-fiber model predictions best match the experimental trends in buckling pressure changes with axial stretch. This study provides experimental and theoretical methods for further investigating the influence of genetic mutations in elastic fibers on buckling behavior and the development of arterial tortuosity.
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影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
15.9
作者：
Li, DY;Faury, G;Keating, MT
通讯作者：
Keating, MT
影响因子：
2.4
作者：
Gleason, Rudolph L.;Dye, Wendy W.;Wilson, Emily;Humphrey, Jay D.
通讯作者：
Humphrey, Jay D.
影响因子：
2.4
作者：
Liu Q;Han HC
通讯作者：
Han HC
储存持续时间对小鼠颈动脉机械行为的影响。
DOI：
10.1115/1.4004415
发表时间：
2011-07
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Amin M;Kunkel AG;Le VP;Wagenseil JE
通讯作者：
Wagenseil JE