Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia.
Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia.
复制标题
DOI：
10.1002/ijgo.13352
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Farquhar C
中科院分区：
文献类型：
--
作者：
Osoti AO;Page ST;Richardson BA;Guthrie BL;Kinuthia J;Polyak SJ;Farquhar C
评估代谢综合征(METS)与高敏C反应蛋白(HsCRP)之间的关系，hsCRP是慢性炎症的生物标志物，也是心血管疾病的独立预测因子，在有/不伴有子痫前期和妊娠期高血压(GHT)的妇女亚组中。在肯尼亚内罗毕进行了一项前瞻性队列研究。对患有先兆子痫或GHT的妇女和产后12周内血压正常的妇女进行了产后6个月的体格、人体测量、空腹血脂、血糖和hsCRP检测。根据体重指数和年龄调整泊松分布的广义线性回归模型被用来估计hsCRP升高与METS的总体和按先兆子痫或GHT分层的相关性。在纳入这项研究的171名妇女中，超敏C反应蛋白升高的风险(>；3 mg/L)在高血压组(调整后的相对风险[ARR]1.70，95%可信区间[CI]1.05-2.73，P=0.03)中显著高于未合并甲状旁腺素的女性(调整后的相对风险[ARR]1.70，95%可信区间[CI]1.05-2.73，P=0.03)，在高血压组(ARR 2.16 95%可信区间1.01-4.62，P=0.04)中显著高于正常血压组(ARR 1.46，95%可信区间0.93-2.28)。产后hsCRP升高的风险增加可以指导纵向机制和干预研究，以减少患有METS的妇女产后心血管疾病的发病率，特别是在先兆子痫或GHT之后。
To evaluate the association between metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hsCRP), a biomarker of chronic inflammation and an independent predictor for cardiovascular disease overall and in subgroups of women with/without pre-eclampsia and gestational hypertension (GHT). A prospective cohort study was conducted in Nairobi, Kenya. Women with pre-eclampsia or GHT and normotensive women within 12 weeks postpartum underwent physical, anthropometric, fasting lipid profile, plasma glucose, and hsCRP measurements at 6 months postpartum. A generalized linear regression model with Poisson distribution adjusted for body mass index and age was used to estimate the association between elevated hsCRP and MetS overall and stratified by pre-eclampsia or GHT. In the 171 women included in the study, risk of elevated hsCRP (>3 mg/L) was greater among women with compared to those without MetS (adjusted relative risk [ARR] 1.70, 95% confidence interval [CI] 1.05–2.73, P=0.03) and was statistically significantly higher in the hypertensive (ARR 2.16 95% CI 1.01–4.62, P=0.04) but not in the normotensive (ARR 1.46, 95% CI 0.93–2.28) group. Increased risk of elevated hsCRP postpartum can guide longitudinal mechanistic and intervention studies to reduce postpartum cardiovascular morbidity in women with MetS, especially after pre-eclampsia or GHT.
登录
查看更多内容
影响因子：
37.8
作者：
Cook NR;Paynter NP;Eaton CB;Manson JE;Martin LW;Robinson JG;Rossouw JE;Wassertheil-Smoller S;Ridker PM
通讯作者：
Ridker PM
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
DOI：
10.1016/j.preghy.2019.08.088
发表时间：
2019-10-01
影响因子：
2.2
作者：
Osoti, Alfred O.;Page, Stephanie T.;Farquhar, Carey
通讯作者：
Farquhar, Carey
DOI：
10.1016/j.preghy.2015.09.007
发表时间：
2015-10-01
影响因子：
2.2
作者：
Murphy, Malia S. Q.;Tayade, Chandrakant;Smith, Graeme N.
通讯作者：
Smith, Graeme N.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.