Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer.
Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer.
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DOI：
10.3390/cancers14010206
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发表时间：
2021-12-31
期刊：
影响因子：
5.2
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Maharjan CK;Mo J;Wang L;Kim MC;Wang S;Borcherding N;Vikas P;Zhang W
雌激素调节人体的关键生理功能，包括女性生殖器官的发育。然而，雌激素信号传导失调（主要由雌激素受体 (ER) 介导）与许多发育、精神和其他疾病（包括癌症）相关。越来越多的研究表明雌激素可调节许多组织内的炎症过程。除了体内产生的雌激素外，人类还不断接触许多外部雌激素，包括植物中天然存在的雌激素和工业中人工合成的雌激素。在这里，我们还将讨论长期暴露于环境雌激素与组织炎症和乳腺癌发展之间的联系。雌激素受体 (ER) 信号在乳腺癌中的致癌作用早已确定。雌激素与细胞核中雌激素受体 (ER) 的相互作用激活雌激素信号传导的基因组通路。相反，雌激素与细胞膜结合的 G 蛋白偶联雌激素受体 (GPER) 的相互作用会激活快速受体介导的信号转导级联。异常的雌激素信号传导增强乳腺上皮细胞增殖、存活和血管生成，因此是乳腺癌发生和进展的重要一步。与此同时，越来越多的研究也为雌激素的促炎或抗炎作用提供了证据。由于本期的其他文章涵盖了雌激素介导的经典 ER 和 GPER 信号传导，因此本综述将讨论雌激素信号传导影响慢性炎症的关键机制以及其如何参与乳腺癌。从植物饮食或接触工业产品中获得的异种雌激素不断地与不同水平的先天雌激素信号相互作用并改变。因此，它们可以调节慢性炎症和乳腺癌的发展。天然异雌激素通常具有抗炎特性，这与其在乳腺癌中的化学保护作用一致。相比之下，合成异雌激素是促炎和致癌化合物，会增加患乳腺癌的风险。本文还强调了重要的异种雌激素，特别关注它们在炎症和乳腺癌中的作用。更好地了解雌激素、炎症和乳腺癌之间的复杂关系将指导可促进乳腺癌预防和治疗的药物的临床研究。
Estrogens regulate key physiological functions in the human body, including the development of female reproductive organs. However, dysregulated estrogen signaling—mainly mediated by estrogen receptors (ER)—is associated with many developmental, mental, and other diseases, including cancer. An increasing number of studies have demonstrated that estrogen modulates inflammatory processes within many tissues. In addition to estrogens made within the body, humans are also constantly exposed to many outside estrogens, naturally occurring in plants and those artificially synthesized in industries. Here, we will also discuss the link between chronic exposure to environmental estrogens with tissue inflammation and breast cancer development. The oncogenic role of estrogen receptor (ER) signaling in breast cancer has long been established. Interaction of estrogen with estrogen receptor (ER) in the nucleus activates genomic pathways of estrogen signaling. In contrast, estrogen interaction with the cell membrane-bound G-protein-coupled estrogen receptor (GPER) activates the rapid receptor-mediated signaling transduction cascades. Aberrant estrogen signaling enhances mammary epithelial cell proliferation, survival, and angiogenesis, hence is an important step towards breast cancer initiation and progression. Meanwhile, a growing number of studies also provide evidence for estrogen’s pro- or anti-inflammatory roles. As other articles in this issue cover classic ER and GPER signaling mediated by estrogen, this review will discuss the crucial mechanisms by which estrogen signaling influences chronic inflammation and how that is involved in breast cancer. Xenoestrogens acquired from plant diet or exposure to industrial products constantly interact with and alter innate estrogen signaling at various levels. As such, they can modulate chronic inflammation and breast cancer development. Natural xenoestrogens generally have anti-inflammatory properties, which is consistent with their chemoprotective role in breast cancer. In contrast, synthetic xenoestrogens are proinflammatory and carcinogenic compounds that can increase the risk of breast cancer. This article also highlights important xenoestrogens with a particular focus on their role in inflammation and breast cancer. Improved understanding of the complex relationship between estrogens, inflammation, and breast cancer will guide clinical research on agents that could advance breast cancer prevention and therapy.
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影响因子：
5
作者：
BERTAZZI, PA;ZOCCHETTI, C;RADICE, L
通讯作者：
RADICE, L
影响因子：
11.2
作者：
Borcherding N;Kusner D;Kolb R;Xie Q;Li W;Yuan F;Velez G;Askeland R;Weigel RJ;Zhang W
通讯作者：
Zhang W
影响因子：
5.2
作者：
Andrade, Juan E.;Ju, Young H.;Baker, Chandra;Doerge, Daniel R.;Helferich, William G.
通讯作者：
Helferich, William G.
DOI：
10.1073/pnas.91.18.8517
发表时间：
1994-08-30
影响因子：
11.1
作者：
ARONICA, SM;KRAUS, WL;KATZENELLENBOGEN, BS
通讯作者：
KATZENELLENBOGEN, BS
影响因子：
8.8
作者：
Brunnberg, Sara;Andersson, Patrik;Hanberg, Annika
通讯作者：
Hanberg, Annika