Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection.

Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection.
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DOI:
10.3389/fmicb.2012.00068
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发表时间:
2012
影响因子:
5.2
通讯作者:
Hirai-Yuki A
Hirai-Yuki A
中科院分区:
生物学2区
文献类型:
--
作者:
Taguchi F;Hirai-Yuki A

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在这篇综述中,我们报道了小鼠肝炎病毒(MHV)的受体,癌胚抗原相关细胞粘附分子1(CEACAM1),是小鼠对MHV感染易感性的重要决定因素。这一发现是通过使用具有两种不同 MHV 受体等位基因形式(Ceacam1a 和 Ceacam1b)的小鼠品系得出的。尽管之前的研究表明易感性是由单个基因 Ceacam1 决定的,但我们最近在嵌合 Ceacam1 基因替换的小鼠中进行的研究表明,其他宿主因素(基因)也参与了易感性。综述了小鼠对 MHV 易感性以及影响其易感性的因素的研究。
In this review, we report that the receptor of mouse hepatitis virus (MHV), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), is an important determinant of mouse susceptibility to MHV infection. This finding was revealed by using mouse strains with two different allelic forms of the MHV receptor, Ceacam1a and Ceacam1b. Although previous studies indicated that susceptibility is determined by a single gene, Ceacam1, our recent work in gene-replaced mice with chimeric Ceacam1 pointed toward the involvement of other host factors (genes) in the susceptibility. Studies on mouse susceptibility to MHV, as well as the factors involved in their susceptibility, are overviewed.
DOI: 10.1084/jem.153.4.832
发表时间: 1981-01-01
影响因子: 15.3
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