Cutaneous lupus erythematosus: diagnosis and treatment.

Cutaneous lupus erythematosus: diagnosis and treatment.
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DOI:
10.1016/j.berh.2013.07.008
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发表时间:
2013-06
期刊:
Best practice & research. Clinical rheumatology
影响因子:
--
通讯作者:
Werth VP
Werth VP
中科院分区:
其他
文献类型:
--
作者:
Okon LG;Werth VP

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皮肤红斑狼疮包括广泛的皮肤病学表现,这可能会或可能不会与系统性疾病的发展。皮肤狼疮分为几种亚型,包括急性皮肤红斑狼疮、亚急性皮肤红斑狼疮和慢性皮肤红斑狼疮。慢性皮肤红斑狼疮包括盘状红斑狼疮、深部红斑狼疮、冻疮性皮肤狼疮和肿胀性狼疮。这些疾病的诊断需要通过体格检查、实验室研究、组织学、抗体血清学和偶尔直接免疫荧光的组合对亚型进行适当分类,同时确保排除全身性疾病。皮肤狼疮的治疗包括对患者进行适当的防晒教育,沿着适当的局部和全身药物。全身性药物适用于广泛性、瘢痕性或难治性疾病。在这篇综述中,我们讨论了CLE的各种亚型的分类和诊断问题,以及提供最新的治疗管理。
Cutaneous lupus erythematosus encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several subtypes, including acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. Chronic cutaneous lupus erythematosus includes discoid lupus erythematosus, lupus erythematosus profundus, chilblain cutaneous lupus, and lupus tumidus. Diagnosis of these diseases requires proper classification of the subtype, through a combination of physical exam, laboratory studies, histology, antibody serology, and occasionally direct immunofluorescence, while ensuring to exclude systemic disease. Treatment of cutaneous lupus consists of patient education on proper sun protection along with appropriate topical and systemic agents. Systemic agents are indicated in cases of widespread, scarring, or treatment-refractory disease. In this review, we discuss issues in classification and diagnosis of the various subtypes of CLE, as well as provide an update on therapeutic management.
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