Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise.
Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise.
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DOI：
10.1016/j.resp.2017.09.017
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发表时间：
2018-01
影响因子：
2.3
通讯作者：
Musch TI
中科院分区：
文献类型：
--
作者：
Smith JR;Ferguson SK;Hageman KS;Harms CA;Poole DC;Musch TI
慢性心力衰竭(CHF)导致呼吸成本增加，需要增加隔膜血流(BF)。补充膳食硝酸盐(NO3-−)可降低运动成本。我们假设，饮食中补充3号−将减轻心力衰竭引起的呼吸成本增加，从而减轻运动期间横隔膜BF的升高。充血性心力衰竭大鼠接受5天的富含−甜菜根汁(n=10)或安慰剂(n=10)。测定静息和亚极量运动(20m/min，5%等级)时呼吸肌BF(放射性标记微球)。左心室梗死面积和正常肺重量组间差异无统计学意义。在次极量运动中，CHF+BR组的隔膜BF显著低于CHF组(CHF+BR：195±28；CHF：309±71mL/min/100g，p=0.04)。CHF+BR组从安静到运动的隔膜BF变化小于CHF(p=0.047)。这些发现表明，饮食中补充3号−可以减少运动中心力衰竭大鼠升高的隔膜血流量，从而为心力衰竭的这一治疗干预提供额外的支持。
Chronic heart failure (CHF) results in a greater cost of breathing and necessitates an elevated diaphragm blood flow (BF). Dietary nitrate (NO3−) supplementation lowers the cost of exercise. We hypothesized that dietary NO3− supplementation would attenuate the CHF-induced greater cost of breathing and thus the heightened diaphragm BF during exercise. CHF rats received either 5 days of NO3− -rich beetroot (BR) juice (CHF+BR, n=10) or a placebo (CHF, n=10). Respiratory muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20 m/min, 5% grade). Infarcted left ventricular area and normalized lung weight were not significantly different between groups. During submaximal exercise, diaphragm BF was markedly lower for CHF+BR than CHF (CHF+BR: 195±28; CHF: 309±71 mL/min/100g, p=0.04). The change in diaphragm BF from rest to exercise was less (p=0.047) for CHF+BR than CHF. These findings demonstrate that dietary NO3− supplementation reduces the elevated diaphragm BF during exercise in CHF rats thus providing additional support for this therapeutic intervention in CHF.
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影响因子：
3.3
作者：
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影响因子：
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DOI：
10.1016/j.jchf.2015.12.013
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影响因子：
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作者：
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