Specialty Tough Hydrogels and Their Biomedical Applications.

Specialty Tough Hydrogels and Their Biomedical Applications.
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DOI:
10.1002/adhm.201901396
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发表时间:
2020-01
影响因子:
10
通讯作者:
Ma M
Ma M
中科院分区:
工程技术1区
文献类型:
--
作者:
Fuchs S;Shariati K;Ma M

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长期以来,水凝胶一直被探索为用于生物医学应用的有吸引力的材料,因为它们具有出色的生物相容性、高含水量和多功能的制造平台,可以制成具有不同理化性质和几何形状的材料。尽管如此,常规水凝胶的机械性能较弱,限制了它们在医疗环境中使用的材料通常需要的持久承载应用中的使用。因此,在不妥协的体内条件下可以延长临床上合适的材料的寿命的机械坚固的水凝胶的制造是非常感兴趣的。这篇综述着重于设计考虑和策略,以构建这种坚韧的水凝胶。几个有前途的进展,建议使用的专业坚韧水凝胶软执行器,药物输送车辆,粘合剂,涂料,并在组织工程设置突出。虽然在这些特殊的坚韧水凝胶被认为可用于临床应用之前仍然存在挑战,但有希望的初步结果无疑激发了对这一胚胎研究领域可能对生物医学界产生的潜在影响的巨大希望。
Hydrogels have long been explored as attractive materials for biomedical applications given their outstanding biocompatibility, high water content, and versatile fabrication platforms into materials with different physiochemical properties and geometries. Nonetheless, conventional hydrogels suffer from weak mechanical properties, restricting their use in persistent load-bearing applications often required of materials used in medical settings. Thus, the fabrication of mechanically robust hydrogels that can prolong the lifetime of clinically suitable materials under uncompromising in vivo conditions is of great interest. This review focuses on design considerations and strategies to construct such tough hydrogels. Several promising advances in the proposed use of specialty tough hydrogels for soft actuators, drug delivery vehicles, adhesives, coatings, and in tissue engineering settings are highlighted. Whilst challenges remain before these specialty tough hydrogels will be deemed translationally acceptable for clinical applications, promising preliminary results undoubtedly spurs great hope in the potential impact this embryonic research field can have on the biomedical community.
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