Brucella - Virulence Factors, Pathogenesis and Treatment.
Brucella - Virulence Factors, Pathogenesis and Treatment.
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布鲁氏菌 - 毒力因子，发病机理和治疗。
DOI：
10.21307/pjm-2018-029
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发表时间：
2018-06-30
影响因子：
2.1
通讯作者：
Bielawska-Drózd A
中科院分区：
文献类型：
--
作者：
Głowacka P;Żakowska D;Naylor K;Niemcewicz M;Bielawska-Drózd A
布鲁氏菌是革兰氏阴性的小杆菌，感染哺乳动物，能够引起称为布鲁氏菌病的疾病。感染导致家畜（绵羊、猪、公羊等）流产和不育。对人类特别危险的是：羊种布氏杆菌、猪种布氏杆菌、流产布氏杆菌和犬种布氏杆菌，它们会引发非特异性症状（流感样表现）。布鲁氏菌杆菌通过宿主细胞、吸入、皮肤擦伤、摄入或粘膜引入。布鲁氏菌最重要的特征是能够在吞噬细胞和非吞噬细胞内存活和繁殖。布鲁氏菌不产生典型的毒力因子：外毒素、溶细胞素、外切酶、质粒、菌毛和耐药形式。主要毒力因子为：内毒素（LPS）、T4 SS分泌系统和BvrR/BvrS系统，这些系统允许细菌与宿主细胞表面相互作用，形成早期、晚期BCV（Brucella Containing Bacterioles），并在细菌繁殖时与内质网（ER）相互作用。布氏杆菌病的治疗以两药疗法为基础，最常见的抗生素组合是：强力霉素与利福平或氟喹诺酮类与利福平。目前，还使用其他方法来破坏布鲁氏菌细胞内复制（牛磺熊去氧胆酸或人参皂苷级分A）。
Brucellae are Gram-negative, small rods infecting mammals and capable of causing disease called brucellosis. The infection results in abortion and sterility in domestic animals (sheeps, pigs, rams etc). Especially dangerous for humans are: Brucella melitensis, Brucella suis, Brucella abortus, and Brucella canis that trigger unspecific symptoms (flu-like manifestation). Brucella rods are introduced via host cells, by inhalation, skin abrasions, ingestion or mucosal membranes. The most important feature of Brucella is the ability to survive and multiply within both phagocytic and non-phagocytic cells. Brucella does not produce classical virulence factors: exotoxin, cytolisins, exoenzymes, plasmids, fimbria, and drug resistant forms. Major virulence factors are: lipopolysaccharide (LPS), T4SS secretion system and BvrR/BvrS system, which allow interaction with host cell surface, formation of an early, late BCV (Brucella Containing Vacuole) and interaction with endoplasmic reticulum (ER) when the bacteria multiply. The treatment of brucellosis is based on two-drug therapy, the most common combinations of antibiotics are: doxycycline with rifampicin or fluoroquinolones with rifampicin. Currently, also other methods are used to disrupt Brucella intracellular replication (tauroursodeoxycholic acid or ginseng saponin fraction A).
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DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Andersen-Nissen, E;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
6.4
作者：
Cardoso PG;Macedo GC;Azevedo V;Oliveira SC
通讯作者：
Oliveira SC
DOI：
10.1084/jem.20030088
发表时间：
2003-08-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Celli J;de Chastellier C;Franchini DM;Pizarro-Cerda J;Moreno E;Gorvel JP
通讯作者：
Gorvel JP
影响因子：
1.1
作者：
Christopher S;Umapathy BL;Ravikumar KL
通讯作者：
Ravikumar KL
影响因子：
16
作者：
Chen, L;Xie, QW;Nathan, C
通讯作者：
Nathan, C