Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in Drug-Free Generalized Anxiety Disorder.
Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in Drug-Free Generalized Anxiety Disorder.
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无药物广泛性焦虑症中杏仁核和颞极之间的异常功能连接
DOI：
10.3389/fnhum.2016.00549
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发表时间：
2016
影响因子：
2.9
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Li W;Cui H;Zhu Z;Kong L;Guo Q;Zhu Y;Hu Q;Zhang L;Li H;Li Q;Jiang J;Meyers J;Li J;Wang J;Yang Z;Li C
杏仁核和背外侧前额叶皮层（DLPFC）在“情绪失调”中发挥重要作用，这对广泛性焦虑症（GAD）的病因学研究产生深远影响。本研究分析了 43 名受试者（21 名未服用药物的 GAD 患者和 22 名匹配的健康对照）的睁眼和闭眼静息态功能 MRI (rs-fMRI)。杏仁核和 DLPFC 被定义为感兴趣区域 (ROI)，用于分析 GAD 患者与健康对照者的功能连接 (FC)。主要发现显示，与健康对照相比，GAD 患者杏仁核和颞极之间的 FC 增加，这在睁眼和闭眼 rs-fMRI 中均发现。并发现 ROI 和主要属于默认模式网络 (DMN) 的大脑区域之间的 FC 发生了改变。这些发现表明杏仁核和颞极之间的异常 FC 可能有助于广泛性焦虑症的病理生理学，并为当前对焦虑症情绪失调的理解提供了见解。
The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in “emotion dysregulation,” which has a profound impact on etiologic research of generalized anxiety disorder (GAD). The present study analyzed both eyes-open and eyes-closed resting state functional MRI (rs-fMRI) of 43 subjects (21 GAD patients with medicine free and 22 matched healthy controls). The amygdala and the DLPFC were defined as regions of interest (ROI) to analyze functional connectivity (FC) in GAD patients compared with healthy controls. The main findings revealed GAD patients had increased FC between the amygdala and the temporal pole compared to healthy controls, which was found in both eyes-open and eyes-closed rs-fMRI. And altered FC between the ROIs and brain regions that mainly belonged to the default mode network (DMN) were found. These findings suggest that the abnormal FC between the amygdala and the temporal pole may contribute to the pathophysiology of GAD, and provide insights into the current understanding of the emotion dysregulation of anxiety disorders.
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