Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans.
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans.
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DOI：
10.1126/science.1176225
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发表时间：
2009-07-10
期刊：
影响因子：
--
通讯作者：
Cox NJ
中科院分区：
文献类型：
--
作者：
Garten RJ;Davis CT;Russell CA;Shu B;Lindstrom S;Balish A;Sessions WM;Xu X;Skepner E;Deyde V;Okomo-Adhiambo M;Gubareva L;Barnes J;Smith CB;Emery SL;Hillman MJ;Rivailler P;Smagala J;de Graaf M;Burke DF;Fouchier RA;Pappas C;Alpuche-Aranda CM;López-Gatell H;Olivera H;López I;Myers CA;Faix D;Blair PJ;Yu C;Keene KM;Dotson PD Jr;Boxrud D;Sambol AR;Abid SH;St George K;Bannerman T;Moore AL;Stringer DJ;Blevins P;Demmler-Harrison GJ;Ginsberg M;Kriner P;Waterman S;Smole S;Guevara HF;Belongia EA;Clark PA;Beatrice ST;Donis R;Katz J;Finelli L;Bridges CB;Shaw M;Jernigan DB;Uyeki TM;Smith DJ;Klimov AI;Cox NJ
自2009年4月发现甲型H1N1流感病毒以来，该病毒含有来自北美和欧亚猪血统的独特的基因片段组合，继续在人类中传播。2009年甲型H1N1流感病毒与其最近亲属有远亲关系，这表明其基因片段已经在很长一段时间内在未被发现的情况下传播。这些病毒的低遗传多样性表明，进入人类的是类似病毒的单个事件或多个事件。预计将适应人类的分子标记目前在2009年甲型H1N1流感病毒中还不存在，这表明以前未被认识到的分子决定因素可能是人类之间传播的原因。在抗原性方面，这些病毒与北美甲型H1N1猪流感病毒相似，但与季节性人类甲型H1N1病毒不同。
Since its identification in April 2009 an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The 2009 A(H1N1) virus is distantly related to its nearest relatives, indicating that its gene segments have been circulating undetected for an extended period. Low genetic diversity among the viruses suggests the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predicted for adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).
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影响因子：
5.8
作者：
Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
3.8
作者：
SHEERAR, MG;EASTERDAY, BC;HINSHAW, VS
通讯作者：
HINSHAW, VS
影响因子：
1.6
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.162366899
发表时间：
2002-08-06
影响因子：
11.1
作者：
Kilbourne, ED;Smith, C;Cox, N
通讯作者：
Cox, N