Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children.
Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children.
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DOI：
10.1038/sj.bjc.6690293
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发表时间：
1999-04
影响因子：
8.8
通讯作者：
Vassal, G
中科院分区：
文献类型：
--
作者：
Avet-Loiseau, H;Vénuat, AM;Terrier-Lacombe, MJ;Lellouch-Tubiana, A;Zerah, M;Vassal, G
应用比较基因组杂交（CGH）技术对23例儿童原始神经外胚层肿瘤（PNET）进行分析。在20例患者中检测到多个染色体不平衡。最常见的染色体是17号染色体，17 q增加（11例）和17 p丢失（8例）。检测到进一步的重复拷贝数变化。9例患者存在7号染色体的额外拷贝，6例患者检测到1 q的增益。一个中等的基因组扩增检测到一个病人，涉及两个网站上的3 p和整个12 p。丢失更为频繁，尤其涉及11号染色体（9例）、10 q（8例）、8号染色体（6例）、X（6例）和3号染色体（5例）以及部分9号染色体（5例）。这些反复出现的染色体变化可能突出了在PNET的发展和/或进展中具有重要作用的新基因的位置。© 1999癌症研究运动
A series of 23 children with primitive neuroectodermal tumours (PNET) were analysed with comparative genomic hybridization (CGH). Multiple chromosomal imbalances have been detected in 20 patients. The most frequently involved chromosome was chromosome 17, with a gain of 17q (11 cases) and loss of 17p (eight cases). Further recurrent copy number changes were detected. Extra copies of chromosome 7 were present in nine patients and gains of 1q were detected in six patients. A moderate genomic amplification was detected in one patient, involving two sites on 3p and the whole 12p. Losses were more frequent, and especially involved the chromosomes 11 (nine cases), 10q (eight cases), 8 (six cases), X (six patients) and 3 (five cases), and part of chromosome 9 (five cases). These recurrent chromosomal changes may highlight locations of novel genes with an important role in the development and/or progression of PNET. © 1999 Cancer Research Campaign
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影响因子：
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通讯作者：
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