fNIRS-Based Differences in Cortical Activation during Tool Use, Pantomimed Actions, and Meaningless Actions between Children with and without Autism Spectrum Disorder (ASD).
fNIRS-Based Differences in Cortical Activation during Tool Use, Pantomimed Actions, and Meaningless Actions between Children with and without Autism Spectrum Disorder (ASD).
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DOI：
10.3390/brainsci13060876
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发表时间：
2023-05-29
期刊：
影响因子：
3.3
通讯作者：
Bhat, Anjana
中科院分区：
文献类型：
--
作者：
Su, Wan-Chun;Culotta, McKenzie;Mueller, Jessica;Tsuzuki, Daisuke;Bhat, Anjana
关键词：
患有自闭症谱系障碍（ASD）的儿童在使用工具和哑剧动作方面有困难。目前的研究利用功能近红外光谱（fNIRS）来研究这些手势困难的神经机制。31名患有和不患有ASD的儿童（年龄（平均值± SE）= 11.0 ± 0.6）完成了一项自然主义的钉锤任务，使用实际的锤子（锤子条件），哑剧锤击动作（哑剧条件），并执行类似关节运动的无意义动作（无意义条件）。ASD儿童的练习成绩较差（练习误差TD = 17.9 ± 1.7; ASD = 27.0 ± 2.6，p < 0.01），与其皮层激活显著相关（R = 0.257 ~ 0.543）。两组都显示左侧激活，但ASD儿童在所有手势条件下表现出更多的双侧激活。与正常发育的儿童相比，ASD儿童表现出下顶叶的过度激活和中/下额叶和中/上级颞区的低激活。我们的研究结果表明，完整的技术推理（典型的左IPL激活），但非典型的视觉空间和本体感受处理（超激活的权利IPL）在ASD儿童的工具使用。这些结果对临床医生和研究人员具有重要意义，他们应该专注于促进/减轻ASD儿童视觉空间和本体感受处理的负担。此外，fNIRS相关的生物标志物可用于通过早期物体游戏/工具使用进行早期识别，并检查基于手势的干预后的神经效应。
Children with autism spectrum disorder (ASD) have difficulties with tool use and pantomime actions. The current study utilized functional near-infrared spectroscopy (fNIRS) to examine the neural mechanisms underlying these gestural difficulties. Thirty-one children with and without ASD (age (mean ± SE) = 11.0 ± 0.6) completed a naturalistic peg-hammering task using an actual hammer (hammer condition), pantomiming hammering actions (pantomime condition), and performing meaningless actions with similar joint motions (meaningless condition). Children with ASD exhibited poor praxis performance (praxis error: TD = 17.9 ± 1.7; ASD = 27.0 ± 2.6, p < 0.01), which was significantly correlated with their cortical activation (R = 0.257 to 0.543). Both groups showed left-lateralized activation, but children with ASD demonstrated more bilateral activation during all gestural conditions. Compared to typically developing children, children with ASD showed hyperactivation of the inferior parietal lobe and hypoactivation of the middle/inferior frontal and middle/superior temporal regions. Our findings indicate intact technical reasoning (typical left-IPL activation) but atypical visuospatial and proprioceptive processing (hyperactivation of the right IPL) during tool use in children with ASD. These results have important implications for clinicians and researchers, who should focus on facilitating/reducing the burden of visuospatial and proprioceptive processing in children with ASD. Additionally, fNIRS-related biomarkers could be used for early identification through early object play/tool use and to examine neural effects following gesture-based interventions.
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影响因子：
2.9
作者：
Bhat AN;Hoffman MD;Trost SL;Culotta ML;Eilbott J;Tsuzuki D;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
3.8
作者：
Fourie, Emily;Palser, Eleanor R.;Rivera, Susan M.
通讯作者：
Rivera, Susan M.
影响因子：
3.2
作者：
Bhat, Anjana Narayan
通讯作者：
Bhat, Anjana Narayan
影响因子：
4.7
作者：
Amonkar N;Su WC;Bhat AN;Srinivasan SM
通讯作者：
Srinivasan SM
影响因子：
4.6
作者：
Federico, Giovanni;Reynaud, Emanuelle;Navarro, Jordan;Lesourd, Mathieu;Gaujoux, Vivien;Lamberton, Franck;Ibarrola, Daniele;Cavaliere, Carlo;Alfano, Vincenzo;Aiello, Marco;Salvatore, Marco;Seguin, Perrine;Schnebelen, Damien;Brandimonte, Maria Antonella;Rossetti, Yves;Osiurak, Francois
通讯作者：
Osiurak, Francois