Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease.
Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease.
复制标题
中枢神经系统与免疫细胞的交互作用及其在健康和疾病中的功能。
DOI：
10.3389/fneur.2021.672455
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Offner H
中科院分区：
文献类型：
--
作者：
Matejuk A;Vandenbark AA;Offner H
免疫系统的作用不仅仅是识别自我与非自我，还包括从早期发育开始维持机体的稳态和完整性，以确保后期器官功能正常。与其他系统不同，中枢神经系统（CNS）与外周免疫机制分离，几十年来，外周免疫机制几乎完全被认为对神经系统有害。新的研究改变了这一观点，并表明血源性免疫细胞（包括适应性和先天性）可以通过神经免疫通讯为CNS提供稳态支持。神经退行性变主要通过常驻脑免疫群体的透镜观察，很少关注外周循环。例如，认知能力下降与外周适应性免疫功能受损有关，但与小胶质细胞的去除无关。靶向神经炎症框架（抑制免疫反应）的药物治疗失败，特别是在神经退行性疾病中，需要重新考虑免疫反应的贡献。了解CNS和免疫系统在健康和疾病中的相互作用对于破译神经破坏性和神经保护性免疫机制以获得更有效的治疗策略至关重要。
The immune system's role is much more than merely recognizing self vs. non-self and involves maintaining homeostasis and integrity of the organism starting from early development to ensure proper organ function later in life. Unlike other systems, the central nervous system (CNS) is separated from the peripheral immune machinery that, for decades, has been envisioned almost entirely as detrimental to the nervous system. New research changes this view and shows that blood-borne immune cells (both adaptive and innate) can provide homeostatic support to the CNS via neuroimmune communication. Neurodegeneration is mostly viewed through the lens of the resident brain immune populations with little attention to peripheral circulation. For example, cognition declines with impairment of peripheral adaptive immunity but not with the removal of microglia. Therapeutic failures of agents targeting the neuroinflammation framework (inhibiting immune response), especially in neurodegenerative disorders, call for a reconsideration of immune response contributions. It is crucial to understand cross-talk between the CNS and the immune system in health and disease to decipher neurodestructive and neuroprotective immune mechanisms for more efficient therapeutic strategies.
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影响因子：
12.7
作者：
Bradl M;Lassmann H
通讯作者：
Lassmann H
影响因子：
15.3
作者：
BOITARD, C;YASUNAMI, R;BACH, JF
通讯作者：
BACH, JF
影响因子：
4.4
作者：
Brombacher, Tiroyaone M.;Nono, Justin K.;Brombacher, Frank
通讯作者：
Brombacher, Frank
影响因子：
3.3
作者：
Antel, Jack P.;Lin, Yun Hsuan;Healy, Luke M.
通讯作者：
Healy, Luke M.
DOI：
10.1084/jem.192.3.393
发表时间：
2000-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Babbe H;Roers A;Waisman A;Lassmann H;Goebels N;Hohlfeld R;Friese M;Schröder R;Deckert M;Schmidt S;Ravid R;Rajewsky K
通讯作者：
Rajewsky K