Modulating nonlinear elastic behavior of biodegradable shape memory elastomer and small intestinal submucosa(SIS) composites for soft tissue repair.
Modulating nonlinear elastic behavior of biodegradable shape memory elastomer and small intestinal submucosa(SIS) composites for soft tissue repair.
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DOI：
10.1016/j.jmbbm.2020.103965
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发表时间：
2020-10
影响因子：
3.9
通讯作者：
Hollister, Scott J.
中科院分区：
文献类型：
--
作者：
Ramaraju, Harsha;Ul-Haque, Anum;Verga, Adam S.;Bocks, Martin L.;Hollister, Scott J.
关键词：
通过开发具有与治疗目标组织相似的机械性能的生物相容性和生物可吸收材料，可以推进用于再生治疗的软组织的结构修复。开发模拟软组织力学的新材料可以减轻基于材料的治疗的许多限制，特别是关于材料对周围组织结构施加的机械应力和变形。然而，许多用于软组织修复的弹性体材料缺乏通过微创手术（MIS）或经导管途径输送的能力，并且需要开放式手术方法进行放置和应用。我们开发了一种生物相容性且完全可生物降解的形状记忆弹性体——聚十二烷二酸甘油酯（PGD），它满足超弹性的要求并表现出形状记忆行为，可作为微创临床手术中再生治疗的新型基底材料。我们之前的工作证明，通过增加聚合物的交联密度，可以控制 12.5% 压缩应变下 1-3 MPa 的切线模量。为了改善对更广泛的机械性能、非线性行为和韧性的控制，我们 1) 改变 PGD 物理交联密度，2) 将不同厚度的猪小肠粘膜下层（SIS，Cook Biotech, Inc.）掺入片材，以及 3）以不同的重量百分比将冻干 SIS 颗粒混合到 PGD 中。拉伸测试 (ASTM D412a) 显示含有 SIS 片材的 PGD 比对照片材更硬 (p < 0.01)。与 PGD 对照相比，将冻干 SIS 颗粒纳入 PGD 会增加失效应变 (p < 0.001)。与 PGD 撕裂样本制备的对照样本相比，具有 1 层片材的测试样本具有更高的撕裂强度 (ASTM D624c) (p < 0.001)。然而，与 PGD 对照相比，掺入 SIS 颗粒降低了 PGD-SIS 0.5wt% 颗粒复合材料的撕裂强度 (p < 0.01)。与对照相比，将 2 层和 4 层片材以及 0.5wt% 颗粒纳入 PGD 会降低复合材料的固定性和恢复性 (p < 0.01)。单轴拉伸下应力应变曲线的非线性建模证明了 PGD-SIS 复合材料在模拟各种非线性软组织时的可调性。这些发现支持使用形状记忆 PGD-SIS 复合材料来设计可植入装置，用于通过微创手术进行的各种软组织再生应用。
Structural repair of soft tissue for regenerative therapies can be advanced by developing bioCompatible and bioresorbable materials with mechanical properties similar to the tissue targeted for therapy. Developing new materials modeling soft tissue mechanics can mitigate many limitations of material based therapies, specifically concerning the mechanical stress and deformation the material imposes on surrounding tissue structures. However, many elastomeric materials used in soft tissue repair lack the ability to be delivered through minimally invasive surgical (MIS) or transcatheter routes and require open surgical approaches for placement and application. We have developed a bioCompatible and fully biodegradable shape memory elastomer, poly-(glycerol dodecanedioate) (PGD), which fulfills the requirements for hyperleasticity and exhibits shape memory behavior to serve as a novel substrate material for regenerative therapy in minimally invasive clinical procedures. Our previous work demonstrated control over the tangent modulus at 12.5% compressive strain between 1–3 MPa by increasing the crosslinking density in the polymer. In order to improve control over a broader range of mechanical properties, nonlinear behavior, and toughness, we 1) varied PGD physical crosslink density, 2) incorporated sheets of porcine small intestinal submucosa (SIS, Cook Biotech, Inc.) with varying thickness, and 3) mixed lyophilized SIS particulates into PGD at different weight percentages. Tensile testing (ASTM D412a) revealed PGD containing SIS sheets of were stiffer than controls (p < 0.01). Incorporating lyophilized SIS particulates into PGD increased the strain to failure (p < 0.001) compared to PGD controls. Test specimens with 1 ply sheets had greater tear strength (ASTM D624c) compared to PGD tear specimens prepared control specimens (p < 0.001). However, incorporating SIS particulates decreased tear strength of PGD-SIS 0.5wt% particulate composites (p < 0.01) compared to PGD controls. Incorporating 2 ply and 4 ply sheets and 0.5wt% particulates into PGD decreased the fixity and recovery of composite materials compared to controls (p < 0.01). Nonlinear modeling of stress strain curves under uniaxial tension demonstrated tunability of PGD-SIS composite materials to model various nonlinear soft tissues. These findings support the use of shape memory PGD-SIS composite materials towards the design of implantable devices for a variety of soft tissue regeneration applications by minimally invasive surgery.
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影响因子：
14
作者：
Migneco, Francesco;Huang, Yen-Chih;Birla, Ravi K.;Hollister, Scott J.
通讯作者：
Hollister, Scott J.
影响因子：
14
作者：
Daemi, Hamed;Rajabi-Zeleti, Sareh;Baharvand, Hossein
通讯作者：
Baharvand, Hossein
DOI：
10.1016/j.jmbbm.2011.08.011
发表时间：
2012-01-01
影响因子：
3.9
作者：
Hassan, M. A.;Hamdi, M.;Noma, A.
通讯作者：
Noma, A.
影响因子：
3.2
作者：
Bhattacharya, A;Mahajan, RL
通讯作者：
Mahajan, RL
高度弹性和可杀伤的电气传播聚（甘油酸甘油）纤维支架。
影响因子：
9.7
作者：
Jeffries, Eric M.;Allen, Robert A.;Gao, Jin;Pesce, Matt;Wang, Yadong
通讯作者：
Wang, Yadong