Highly elastic and suturable electrospun poly(glycerol sebacate) fibrous scaffolds.
Highly elastic and suturable electrospun poly(glycerol sebacate) fibrous scaffolds.
复制标题
高度弹性和可杀伤的电气传播聚（甘油酸甘油）纤维支架。
DOI：
10.1016/j.actbio.2015.02.005
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发表时间：
2015-05
影响因子：
9.7
通讯作者：
Wang, Yadong
中科院分区：
文献类型：
--
作者：
Jeffries, Eric M.;Allen, Robert A.;Gao, Jin;Pesce, Matt;Wang, Yadong
聚癸二酸甘油酯 (PGS) 是一种热交联弹性体，因其弹性、可降解性和促再生炎症反应而适用于组织再生。 PGS 支架中的孔隙通常是由致孔剂浸出产生的，这会损害强度。生产纤维 PGS 支架的方法非常有限。静电纺丝是实验室规模生产纤维支架最广泛使用的方法。静电纺丝 PGS 本身具有挑战性，需要载体聚合物，如果不去除，可能会影响材料性能。我们报告了一种简单的静电纺丝方法，可以生产独特的 PGS 纤维，同时保持热交联 PGS 所需的机械和细胞相容性特性。与多孔 PGS 泡沫相比，纤维 PGS 的拉伸强度高出 5 倍，并且缝线保持力增强。此外，还观察到相似的模量和弹性回复率。纤维 PGS 片材的最后一个优点是能够通过热交联过程中发生的纤维粘合来创建多层结构。总而言之，这些高弹性纤维 PGS 支架将为组织工程和再生医学带来新的方法。
Poly(glycerol sebacate) (PGS) is a thermally-crosslinked elastomer suitable for tissue regeneration due to its elasticity, degradability, and pro-regenerative inflammatory response. Pores in PGS scaffolds are typically introduced by porogen leaching, which compromises strength. Methods for producing fibrous PGS scaffolds are very limited. Electrospinning is the most widely used method for laboratory scale production of fibrous scaffolds. Electrospinning PGS by itself is challenging, necessitating a carrier polymer which can affect material properties if not removed. We report a simple electrospinning method to produce distinct PGS fibers while maintaining the desired mechanical and cytocompatibility properties of thermally crosslinked PGS. Fibrous PGS demonstrated 5 times higher tensile strength and increased suture retention compared to porous PGS foams. Additionally, similar modulus and elastic recovery were observed. A final advantage of fibrous PGS sheets is the ability to create multi-laminate constructs due to fiber bonding that occurs during thermal crosslinking. Taken together, these highly elastic fibrous PGS scaffolds will enable new approaches in tissue engineering and regenerative medicine.
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影响因子：
9.5
作者：
Ifkovits, Jamie L.;Devlin, Jeffrey J.;Eng, George;Martens, Timothy P.;Vunjak-Novakovic, Gordana;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
4.9
作者：
Crapo, Peter M.;Gao, Jin;Wang, Yadong
通讯作者：
Wang, Yadong
影响因子：
4.5
作者：
Jaafar, Israd H.;Ammar, Mohamed M.;Coulter, John P.
通讯作者：
Coulter, John P.
影响因子：
38.3
作者：
通讯作者：
--
影响因子：
14
作者：
Crapo, Peter M.;Wang, Yadong
通讯作者：
Wang, Yadong