Stress reduction and preventing hypertension: preliminary support for a psychoneuroendocrine mechanism.
Stress reduction and preventing hypertension: preliminary support for a psychoneuroendocrine mechanism.
复制标题
减轻压力和预防高血压：对心理神经内分泌机制的初步支持。
DOI：
--
复制
发表时间：
1995
影响因子：
2.6
通讯作者：
P. Macrae
中科院分区：
文献类型：
--
作者：
K. Walton;N. Pugh;Paul Gelderloos;P. Macrae
我们的目标是确定与内分泌相关的机制，这些机制能够调节应激减轻对高血压心脏病的预防效果。由于减压的有益效果会随着时间的推移而增加，这项横断面的描述性研究试图在没有练习系统的减压技术的健康学生(平均压力组，n=33)和练习了8.5年的超验冥想(TM)技术的类似组(低压力组，LS组，n=22)之间寻找差异。这两组学生在年龄和学习领域上是匹配的，他们进行了定时的尿液收集，包括(分别)一天的整个清醒和睡眠部分。他们还完成了情绪状态简介和状态-特质焦虑问卷，这是一种对主观压力水平敏感的自我报告工具。尿样用放射免疫法分析肾上腺皮质类固醇，用原子吸收光谱分析Na+、K+、Mg2+、Ca2+和Zn2+，用反相高效液相色谱仪和分光光度法分析神经递质代谢物。这两组人在大多数指标上存在显著差异。具体地说，LS组的皮质醇和醛固酮水平较低，而脱氢表雄酮硫酸盐(DS)和5-羟色胺代谢物5-羟吲哚乙酸(5-HIAA)的水平较高。钠、钙、锌和去甲肾上腺素代谢物香草扁桃酸(VMA)的排泄量也较低，Na+/K+比率、情绪障碍和焦虑也较低。在练习TM的女性中，皮质醇与练习TM的月数呈负相关，DS与练习TM的月数呈正相关。结果发现，情绪状态、肾上腺皮质活动和肾功能的改善可能是缓解压力的预防和治疗效果的因素。由于这些参数的次优水平是慢性主观压力造成的，这些发现为高血压心脏病是可以避免的论点增加了机械支持，即使在现代工业化社会也是如此。
Our objective was to identify endocrine-related mechanisms capable of mediating preventive effects of stress reduction in hypertensive heart disease. Since beneficial effects of stress reduction accrue over time, this cross-sectional, descriptive study sought differences between healthy students not practicing a systematic technique for reducing stress (the average stress, or AS, group, n = 33) and a similar group who for 8.5 years had practiced the Transcendental Meditation (TM) technique, used widely to reduce stress (the low stress, or LS, group, n = 22). The two groups of students, matched for age and area of study, performed timed collections of urine that included (separately) the entire waking and sleeping portions of 1 day. They also completed the Profile of Mood States and the State-Trait Anxiety Inventory, self-report instruments sensitive to subjective level of stress. Urine samples were analyzed for adrenocortical steroids by radioimmunoassay, for Na+, K+, Mg2+, Ca2+, and Zn2+ by atomic absorption spectrometry, and for neurotransmitter metabolites by reverse-phase, high-performance, liquid chromatography, and spectrophotometry. The two groups differed significantly on most measures. Specifically, the LS group was lower in cortisol and aldosterone and higher in dehydroepiandrosterone sulfate (DS) and the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA). Excretion of sodium, calcium, zinc, and the norepinephrine metabolite, vanillylmandelic acid (VMA), was also lower in this group, as were Na+/K+ ratio, mood disturbance, and anxiety. In women practicing TM, cortisol correlated inversely and DS directly with number of months of TM practice. The results identify improvements in mood state, adrenocortical activity, and kidney function as probable factors in the preventive and treatment effects of stress reduction. Because suboptimal levels of these parameters result from chronic, subjective stress, the findings add mechanistic support to the contention that hypertensive heart disease is avoidable, even in modern industrialized societies.
登录
查看更多内容
逃避盐皮质激素的钠潴留作用：ANF 和肾内激素系统的作用。
影响因子：
19.6
作者：
Gonzalez-Campoy,JM;Romero,JC;Knox,FG
通讯作者：
Knox,FG
影响因子：
5.5
作者：
A. Nafziger;David M. Herrington;T. Bush
通讯作者：
A. Nafziger;David M. Herrington;T. Bush
特质敌意与心血管反应性之间的关系：定量回顾和分析。
影响因子：
3.7
作者：
Suls,J;Wan,CK
通讯作者：
Wan,CK
影响因子：
56.9
作者：
GUYTON, AC
通讯作者：
GUYTON, AC
糖皮质激素诱导 DTT1 MF-2 平滑肌细胞中 α 1B 肾上腺素受体基因的转录和表达。
DOI：
10.1172/jci115315
发表时间：
1991
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Sakaue,M;Hoffman,BB
通讯作者：
Hoffman,BB