Magnetic particle imaging for radiation-free, sensitive and high-contrast vascular imaging and cell tracking.

Magnetic particle imaging for radiation-free, sensitive and high-contrast vascular imaging and cell tracking.
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无辐射,灵敏和高对比度血管成像和细胞跟踪的磁性粒子成像。

DOI:
10.1016/j.cbpa.2018.04.014
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发表时间:
2018-08
影响因子:
7.8
通讯作者:
Conolly SM
Conolly SM
中科院分区:
生物学2区
文献类型:
--
作者:
Zhou XY;Tay ZW;Chandrasekharan P;Yu EY;Hensley DW;Orendorff R;Jeffris KE;Mai D;Zheng B;Goodwill PW;Conolly SM

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磁粒子成像(MPI)是一种新兴的无电离辐射生物医学示踪成像技术,它直接成像超顺磁性氧化铁纳米颗粒(SPIO)的强烈磁化强度。MPI提供了理想的图像对比度,因为MPI显示背景组织的零信号。此外,信号在组织中的深度为零衰减,允许在任何位置对人体内部深处进行定量成像。最近的工作证明了MPI在健壮、灵敏的血管成像和细胞跟踪方面的潜力,具有与核医学相当的高对比度和剂量限制灵敏度。为了促进MPI的未来应用,这一新的生物医学成像领域正在欢迎拥有成像物理、磁性纳米粒子合成和功能化、纳米物理和小动物成像应用方面专业知识的研究人员。
Magnetic particle imaging (MPI) is an emerging ionizing radiation-free biomedical tracer imaging technique that directly images the intense magnetization of superparamagnetic iron oxide nanoparticles (SPIOs). MPI offers ideal image contrast because MPI shows zero signal from background tissues. Moreover, there is zero attenuation of the signal with depth in tissue, allowing for imaging deep inside the body quantitatively at any location. Recent work has demonstrated the potential of MPI for robust, sensitive vascular imaging and cell tracking with high contrast and dose-limited sensitivity comparable to nuclear medicine. To foster future applications in MPI, this new biomedical imaging field is welcoming researchers with expertise in imaging physics, magnetic nanoparticle synthesis and functionalization, nanoscale physics, and small animal imaging applications.
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