Trends in malaria epidemiological factors following the implementation of current control strategies in Dangassa, Mali.
Trends in malaria epidemiological factors following the implementation of current control strategies in Dangassa, Mali.
复制标题
DOI：
10.1186/s12936-022-04058-0
复制
发表时间：
2022-02-23
期刊：
影响因子：
3
通讯作者：
Doumbia S
中科院分区：
文献类型：
--
作者：
Touré M;Keita M;Kané F;Sanogo D;Kanté S;Konaté D;Diarra A;Sogoba N;Coulibaly MB;Traoré SF;Alifrangis M;Diakité M;Shaffer JG;Krogstad DJ;Doumbia S
在过去的十年中，三种策略减少了非洲、亚洲和美洲流行地区的严重疟疾病例和死亡，特别是：（1）以青蒿素为基础的联合疗法（ACT）； (2) 经杀虫剂处理的蚊帐（ITN）； (3) 妊娠期间用磺胺多辛-乙胺嘧啶进行间歇性预防治疗 (IPTp)。这项研究的目的是调查马里丹加萨的社区，该地区于 2015 年实施了两项额外的控制策略：ITN 全民覆盖和 5 岁以下儿童的季节性疟疾化学预防 (SMC)。这是一项前瞻性研究，基于 1401 名受试者的滚动纵向队列，这些受试者参加了每两年一次的无症状恶性疟原虫感染流行率调查，并在 2012 年至 2020 年期间对人类疾病（单纯性疟疾）的发病率进行了持续监测。进行了昆虫学采集，以根据拟除虫菊酯喷雾捕捉、人类登陆捕捉和酶联免疫吸附测定来检查传播强度(ELISA) 检测环子孢子抗原。 2012 年，从社区人口普查名单中随机抽样家庭后，共有 1401 名各个年龄段的参与者参加了这项研究。 Dangassa 的感染率极高，雨季开始时为 9.5% 至 62.8%，雨季结束时为 15.1% 至 66.7%。同样，丹加萨的每间房屋的病媒数量、叮咬率、子孢子率和昆虫接种率 (EIR) 也显着增加。这项研究的结果与丹加萨逐步实施有效的疟疾控制策略是一致的。基线时（2012-2014 年），恶性疟原虫的患病率超过 60%，随后从 2015 年开始逐年显着下降。 < 5 岁儿童中无并发症感染的发生率更高，而 5-14 岁儿童中无症状感染的发生率更高。从 2015 年到 2020 年，还观察到 EIR 显着下降。同样，在研究期间，载体密度、子孢子率和 EIR 也大幅下降。在丹加萨有效实施两项主要疟疾预防战略，大大有助于减少 2015 年至 2020 年无症状和有症状疟疾的发生。
Over the past decade, three strategies have reduced severe malaria cases and deaths in endemic regions of Africa, Asia and the Americas, specifically: (1) artemisinin-based combination therapy (ACT); (2) insecticide-treated bed nets (ITNs); and, (3) intermittent preventive treatment with sulfadoxine-pyrimethamine in pregnancy (IPTp). The rationale for this study was to examine communities in Dangassa, Mali where, in 2015, two additional control strategies were implemented: ITN universal coverage and seasonal malaria chemoprevention (SMC) among children under 5 years old. This was a prospective study based on a rolling longitudinal cohort of 1401 subjects participating in bi-annual smear surveys for the prevalence of asymptomatic Plasmodium falciparum infection and continuous surveillance for the incidence of human disease (uncomplicated malaria), performed in the years from 2012 to 2020. Entomological collections were performed to examine the intensity of transmission based on pyrethroid spray catches, human landing catches and enzyme-linked immunosorbent assay (ELISA) testing for circumsporozoite antigen. A total of 1401 participants of all ages were enrolled in the study in 2012 after random sampling of households from the community census list. Prevalence of infection was extremely high in Dangassa, varying from 9.5 to 62.8% at the start of the rainy season and from 15.1 to 66.7% at the end of the rainy season. Likewise, the number of vectors per house, biting rates, sporozoites rates, and entomological inoculation rates (EIRs) were substantially greater in Dangassa. The findings for this study are consistent with the progressive implementation of effective malaria control strategies in Dangassa. At baseline (2012–2014), prevalence of P. falciparum was above 60% followed by a significant year-to-year decease starting in 2015. Incidence of uncomplicated infection was greater among children < 5 years old, while asymptomatic infection was more frequent among the 5–14 years old. A significant decrease in EIR was also observed from 2015 to 2020. Likewise, vector density, sporozoite rates, and EIRs decreased substantially during the study period. Efficient implementation of two main malaria prevention strategies in Dangassa substantially contribute to a reduction of both asymptomatic and symptomatic malaria from 2015 to 2020.
登录
查看更多内容
影响因子：
3.3
作者：
Coulibaly, Drissa;Travassos, Mark A.;Gaudart, Jean
通讯作者：
Gaudart, Jean
影响因子：
2.1
作者：
BEIER, JC;PERKINS, PV;KOECH, DK
通讯作者：
KOECH, DK
影响因子：
3
作者：
Konate, Drissa;Diawara, Sory, I;Diakite, Mahamadou
通讯作者：
Diakite, Mahamadou
DOI：
10.3390/ijerph17113982
发表时间：
2020-06-01
影响因子：
--
作者：
Cissoko, Mady;Sagara, Issaka;Gaudart, Jean
通讯作者：
Gaudart, Jean
DOI：
10.3390/ijerph17176339
发表时间：
2020-08-31
影响因子：
--
作者：
Ateba FF;Febrero-Bande M;Sagara I;Sogoba N;Touré M;Sanogo D;Diarra A;Magdalene Ngitah A;Winch PJ;Shaffer JG;Krogstad DJ;Marker HC;Gaudart J;Doumbia S
通讯作者：
Doumbia S