Aging alters reactivity of microvascular resistance networks in mouse gluteus maximus muscle.
Aging alters reactivity of microvascular resistance networks in mouse gluteus maximus muscle.
复制标题
衰老改变小鼠臀大肌微血管阻力网络的反应性。
DOI：
10.1152/ajpheart.00368.2014
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Segal,StevenS
中科院分区：
文献类型：
--
作者：
Sinkler,ShenghuaY;Segal,StevenS
Aging occurs with enhanced sympathetic nerve activity and endothelial dysfunction; however, little is known of how successive branches of microvascular resistance networks are affected in vivo. We questioned whether vascular reactivity is altered differentially along resistance networks with advanced age. The left gluteus maximus muscle of anesthetized 4-mo-old and 24-mo-old male C57BL/6 mice (Young and Old, respectively) was exposed for intravital microscopy and superfused with physiological salt solution (3 ml/min; pH 7.4, 34°C). Spontaneous vasomotor tone increased progressively from proximal feed arteries (FA) and first-order (1A) arterioles through distal second-order (2A) and third-order (3A) arterioles and was ∼15% greater in 2A and 3A of Old versus Young. Vasoconstriction during elevated superfusion Po2increased with branch order and to a greater extent in Young. Peak constrictions to phenylephrine [α1adrenoreceptor (α1AR) agonist] were similar for FA and 1A of both ages and ∼20% greater for 2A and 3A of Young. Across arterioles (but not FA), constrictions to UK 14304 (α2AR agonist) were depressed ∼30% in Old versus Young. Thus advanced age attenuated vasoconstriction to O2throughout networks while blunting vasoconstriction to α1AR and α2AR activation in arterioles. With ACh, endothelium-dependent dilation (EDD) was ∼20% greater in FA of Young yet was approximately twofold greater for 2A and 3A of Old. Sodium nitroprusside evoked maximal dilations similar to ACh. Thus, with advanced age, EDD was attenuated in FA while robust in distal arterioles having enhanced vasomotor tone. We conclude that advanced age differentially alters reactivity among branches of microvascular resistance networks.
登录
查看更多内容
女性肢体血管电导峰值的年龄和区域特异性。
DOI：
10.1152/japplphysiol.00825.2005
发表时间：
2005
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Ridout,SamuelJ;Parker,BethA;Proctor,DavidN
通讯作者：
Proctor,DavidN
骨骼肌反应性充血对氧张力的依赖性。
DOI：
10.1152/ajpheart.1977.233.2.h289
发表时间：
1977
期刊：
The American journal of physiology
影响因子：
--
作者：
R. Tuma;L. Lindbom;K. Arfors
通讯作者：
K. Arfors
影响因子：
20.1
作者：
FABER, JE
通讯作者：
FABER, JE
DOI：
10.1093/geronj/42.6.660
发表时间：
1987-11-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
IRION, GL;VASTHARE, US;TUMA, RF
通讯作者：
TUMA, RF
影响因子：
--
作者：
JACKSON, WF
通讯作者：
JACKSON, WF